Evidence map›Paper›PMID 33995343›Full record

ArticleFrontiers in immunology2021

Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner.

Andreas Linder, Viktoria Bothe, Nicolas Linder, Paul Schwarzlmueller, Frank Dahlström, Christoph Bartenhagen, Martin Dugas, Dharmendra Pandey, Julia Thorn-Seshold, Daniel F R Boehmer and 9 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  6. Article
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  8. Article
  9. Article
  10. Article
  11. Molecular Analysis of Copy-Back Defective Interfering RNAs of Morbilliviruses.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  12. Enhanced production yields of rVSV-SARS-CoV-2 vaccine using Fibra-CelFrontiers in bioengineering and biotechnology · 2024
    Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. A Virus Is a Community: Diversity within Negative-Sense RNA Virus Populations.Microbiology and molecular biology reviews : MMBR · 2022
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Andreas LinderDivision of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
Viktoria BotheDivision of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
Nicolas LinderDivision of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
Paul SchwarzlmuellerDivision of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
Frank DahlströmDivision of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
Christoph BartenhagenInstitute of Medical Informatics, University of Münster, Münster, Germany.
Martin DugasInstitute of Medical Informatics, University of Münster, Münster, Germany.
Dharmendra PandeyDivision of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
Julia Thorn-SesholdDivision of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
Daniel F R BoehmerDivision of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
Lars M KoenigDivision of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
Sebastian KoboldDivision of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
Max SchnurrDivision of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
Johannes RaedlerDivision of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
Giulia SpielmannDivision of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
Hadi KarimzadehDivision of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
Andreas SchmidtDivision of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
Stefan EndresDivision of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
Simon RothenfusserDivision of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
LMU Klinikum · DELudwig-Maximilians-Universität München · DEHelmholtz Zentrum München · DEUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Replication competent vesicular stomatitis virus (VSV) is the basis of a vaccine against Ebola and VSV strains are developed as oncolytic viruses. Both functions depend on the ability of VSV to induce adequate amounts of interferon-α/β. It is therefore important to understand how VSV triggers interferon responses. VSV activates innate immunity

Indexed as

Genome, ViralMutationVirus ReplicationAnimalsCell LineDEAD Box Protein 58Host-Pathogen InteractionsHumansImmunomodulationReceptors, ImmunologicRNA, ViralVesicular StomatitisVesicular stomatitis Indiana virusDEAD Box Protein 58Receptors, ImmunologicRIGI protein, humanRNA, Viraldefective interfering genomenucleic acid sensingpathogen associated molecular pattern (PAMP)pattern recognition receptor (PRR)retinoid acid inducible gene I (RIG-I)vesicular stomatitis virus (VSV)

Identifiers

PMID33995343
PMCPMC8119886
OpenAlexW3158082184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.