Evidence map›Paper›PMID 33995276›Full record

Observational studyFrontiers in endocrinology2021

Complications of Pregnancy and the Risk of Developing Endometrial or Ovarian Cancer: A Case-Control Study.

Yang Liu, Xingyu Chen, Jiayi Sheng, Xinyi Sun, George Qiaoqi Chen, Min Zhao, Qi Chen

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Yang LiuSchool of Medicine, Nanjing Medical University, Nanjing, China.
Xingyu ChenSchool of Medicine, Nanjing Medical University, Nanjing, China.
Jiayi ShengSchool of Medicine, Nanjing Medical University, Nanjing, China.
Xinyi SunDepartment of Obstetrics & Gynaecology, The University of Auckland, Auckland, New Zealand.
George Qiaoqi ChenSchool of Medicine, The University of Manchester, North Manchester, United Kingdom.
Min ZhaoDepartment of Gynaecology, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi, China.
Qi ChenDepartment of Obstetrics & Gynaecology, The University of Auckland, Auckland, New Zealand.
Nanjing Medical University · CNUniversity of Auckland · NZNanjing Maternity and Child Health Care Hospital · CNUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The association of complications of pregnancy and the risk of developing gynecological cancer is controversial with the limited study. In this study, we investigated the association of preeclampsia, or gestational diabetes mellitus (GDM), or large for gestational age (LGA), or intrauterine growth restriction (IUGR) and the risk of endometrial or ovarian cancer. Methods: In this case-control study, 189 women with endometrial cancer and 119 women with ovarian cancer were included. 342 women without gynecological cancers were randomly selected as a control group. Data on the history of pregnancy and age at diagnosis of gynecological cancer as well as the use of intrauterine devices (IUDs) were collected. Results: Women with a history of preeclampsia or IUGR did not have an increased risk of developing endometrial or ovarian cancer. While women with a history of GDM or with the delivery of LGA infant increased the risk of developing endometrial cancer but not ovarian cancer. The odds of women with a history of GDM or with the delivery of LGA infant developing endometrial cancer was 2.691 (95% CI: 1.548, 4.3635, p=0.0003), or 6.383 (95% CI: 2.812, 13.68, p<0.0001) respectively, compared to the controls. The odds ratio of women who did not use IUDs developing ovarian cancer was 1.606 (95% CI: 1.057, 2.434), compared to the controls. There was no association of age at first birth and developing endometrial or ovarian cancer. Conclusion: Our observational data suggested that GDM and delivery of an LGA infant are associated with an increased risk of endometrial cancer.

Indexed as

Pregnancy ComplicationsAdultAgedBirth WeightCase-Control StudiesDiabetes, GestationalDisease SusceptibilityEndometrial NeoplasmsFemaleFetal Growth RetardationFetal MacrosomiaGestational AgeHumansMiddle AgedOvarian NeoplasmsPre-Eclampsiaendometrial cancerGDMIUGRovarian cancerpreeclampsia

Identifiers

PMID33995276
PMCPMC8121171
OpenAlexW3161437201

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.