ArticleFrontiers in physiology2021
A Prospective Evaluation of the Acute Effects of High Altitude on Cognitive and Physiological Functions in Lowlanders.
Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cognitive Performance After Acute Exposure to Altitude - Part II
The Study on Effects of Acute Exposure to High Altitude Hypoxia on Cognitive Function in Lowlanders
Who cites it
25 citing papers in PubMed.
- Cold stress impacts cognitive performance in healthy volunteers: results from a randomized, controlled, cross-over study.Scientific reports · 2026Trial
- Effect of oxygen supplementation on cognitive performance among HEMS providers after acute exposure to altitude: the HEMS II randomized clinical trial.Scandinavian journal of trauma, resuscitation and emergency medicine · 2024Trial
- Simulated Acute Hypobaric Hypoxia Effects on Cognition in Helicopter Emergency Medical Service Personnel - A Randomized, Controlled, Single-Blind, Crossover Trial.Human factors · 2024Trial
- Surgical masks and filtering facepiece class 2 respirators (FFP2) have no major physiological effects at rest and during moderate exercise at 3000-m altitude: a randomised controlled trial.Journal of travel medicine · 2023Trial
- Review
- Neural-behavioral dissociation under acute high-altitude stress: an exploratory ERP study of non-specific neural recruitment and rTMS effects.Frontiers in behavioral neuroscience · 2026Article
- Early adaptation to high-altitude: Mood and cognitive responses at simulated 4500 m.Physiological reports · 2025Article
- DNA methylation in adaptation to high-altitude environments and pathogenesis of related diseases.Human genomics · 2025Review
- Impact of high-altitude exposure on cerebral lobe functions in climbers: insights from the Nepali Himalayas.Frontiers in systems neuroscience · 2025Article
- Cognitive Impairment Mechanisms in High-Altitude Exposure: Proteomic and Metabolomic Insights.Journal of proteome research · 2024Article
- Combined Effects of Moderate Hypoxia and Sleep Restriction on Mental Workload.Clocks & sleep · 2024Article
- Nitronyl Nitroxide Ameliorates Hypobaric Hypoxia-Induced Cognitive Impairment in Mice by Suppressing the Oxidative Stress, Inflammatory Response and Apoptosis.Neurochemical research · 2024Article
- A review of methods for assessment of cognitive function in high-altitude hypoxic environments.Brain and behavior · 2024Review
- Associations between sugar-sweetened beverages consumption, duration of physical exercise, and depressive symptoms among Tibetan university students at high altitude.Frontiers in psychology · 2024Article
- The Question is Still Open: Is Supplemental Oxygen Enhancing Performance in Professional Athletes at High Altitude or Not?Sports medicine (Auckland, N.Z.) · 2023Article
- The Oxygen Cascade from Atmosphere to Mitochondria as a Tool to Understand the (Mal)adaptation to Hypoxia.International journal of molecular sciences · 2023Review
- Editorial: Neurological, neurophysiological, psychological and psychiatric effects of high altitude and hypoxia.Frontiers in physiology · 2023Article
- Cognition and Neuropsychological Changes at Altitude-A Systematic Review of Literature.Brain sciences · 2022Review
- Sleep, short-term memory, and mood states of volunteers with increasing altitude.Frontiers in psychiatry · 2022Article
- The role of post-translational modifications in driving abnormal cardiovascular complications at high altitude.Frontiers in cardiovascular medicine · 2022Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive function impairment due to high altitude exposure has been reported with some contradictory results regarding the possible selective cognitive domain involvement. We prospectively evaluated in 36 lowlanders, exposed for 3 consecutive days to an altitude of 3,269 m, specific cognitive abilities (attention, processing speed, and decision-making) required to safely explore the mountains, as well as to work at altitude. We simultaneously monitored the physiological parameters. Our study provides evidence of a reduced processing speed in lowlanders when exposed to altitude in the first 24 h. There was a fairly quick recovery since this impairment was no more detectable after 36 h of exposure. There were no clinically relevant effects on decision-making, while psychomotor vigilance was unaffected at altitude except for individuals with poor sleep. Significant changes were seen in physiological parameters (increased heart rate and reduced peripheral oxygen saturation). Our results may have practical implications, suggesting that individuals should practice prudence with higher ascent when performing risky activities in the first 24-36 h, even at altitudes below 3,500 m, due to an impairment of the cognitive performance that could worsen and lead to accidents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.