Evidence map›Paper›PMID 33995033›Full record

ArticleFrontiers in pharmacology2021

SARS-CoV-2 Switches 'on' MAPK and NFκB Signaling via the Reduction of Nuclear DUSP1 and DUSP5 Expression.

Swati Goel, Fatemeh Saheb Sharif-Askari, Narjes Saheb Sharif Askari, Bushra Madkhana, Ahmad Munzer Alwaa, Bassam Mahboub, Adel M Zakeri, Elaref Ratemi, Rifat Hamoudi, Qutayba Hamid and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 78 citations in OpenAlex.

  1. p53 and p21 Status Influences Cellular Response to Metformin inCurrent issues in molecular biology · 2026
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  7. Association of plasma microRNAs with COVID-19 severity and outcome.Journal, genetic engineering & biotechnology · 2024
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  11. Single-Cell Sequencing Reveals Functional Alterations in Tuberculosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  12. Review
  13. Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Swati GoelSharjah Institute of Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Fatemeh Saheb Sharif-AskariSharjah Institute of Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Narjes Saheb Sharif AskariSharjah Institute of Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Bushra MadkhanaSharjah Institute of Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Ahmad Munzer AlwaaDepartment of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Bassam MahboubSharjah Institute of Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Adel M ZakeriDepartment of Plant Production, Faculty of Agriculture and Food Sciences, King Saud University, Riyadh, Saudi Arabia.
Elaref RatemiJubail- Industrial College, Department of Chemical and Process Engineering Technology, Jubail- Industrial City, Al Jubail, Saudi Arabia.
Rifat HamoudiSharjah Institute of Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Qutayba HamidSharjah Institute of Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
Rabih HalwaniSharjah Institute of Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
University of Sharjah · AEJubail Industrial College · SAKing Saud University · SARashid Hospital · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitogen-activated protein kinases (MAPK) and NF-kappaB (NF-κB) pathway regulate many cellular processes and are essential for immune cells function. Their activity is controlled by dual-specificity phosphatases (

Indexed as

chroloquineCOVID-19DUSP1DUSP5MAPKNFkBSARS-CoV-2

Identifiers

PMID33995033
PMCPMC8114414
OpenAlexW3153563636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.