Evidence map›Paper›PMID 33994919›Full record

ArticleFrontiers in neuroscience2021

A Close Examination of the Use of Systolic Time Intervals in the Calculation of Impedance Derived Cardiac Autonomic Balance and Regulation.

Cameron R Wiley, Vida Pourmand, Julian F Thayer, DeWayne P Williams

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Stress-induced pacemaker desynchronization in the sinoatrial node.Frontiers in cardiovascular medicine · 2026
    Article
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Cameron R WileyDepartment of Psychological Science, University of California, Irvine, Irvine, CA, United States.
Vida PourmandDepartment of Psychology, Western Washington University, Bellingham, WA, United States.
Julian F ThayerDepartment of Psychological Science, University of California, Irvine, Irvine, CA, United States.
DeWayne P WilliamsDepartment of Psychological Science, University of California, Irvine, Irvine, CA, United States.
University of California, Irvine · USWestern Washington University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditionally, impedance derived measures of cardiac autonomic balance (CAB) and regulation (CAR) are calculated using indices of heart rate variability (HRV) that primarily reflect parasympathetic nervous system activity (e.g., high-frequency HRV | HF-HRV) and pre-ejection period (PEP; a systolic time interval and measure of sympathetic activity). However, HF-HRV and PEP are considered measures of chronotropic and inotropic cardiac influence, respectively. Left ventricular ejection time (LVET) is a systolic time interval that reflects sympathetic chronotropic influence, and therefore may be a more appropriate measure for calculating CAB and CAR compared to PEP. Thus, the current study evaluates both PEP and LVET in the calculation of CAB and CAR. Data from 158 healthy participants (mean age = 19.09 years old, SD = 1.84 years) were available for analyses. CAB and CAR values were calculated using both HF-HRV and the root mean square of successive differences, in addition to both PEP and LVET, in accordance with previously established guidelines. Analyses showed that correlations were significantly weaker between CAB and CAR calculated using LVET for both HF (

Indexed as

cardiac autonomic balancecardiac autonomic regulationheart rate variabilityleft ventricular ejection timepre-ejection period

Identifiers

PMID33994919
PMCPMC8119784
OpenAlexW3157364641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.