Evidence map›Paper›PMID 33994608›Full record

ArticleComputational statistics & data analysis2021

Optimal treatment regimes for competing risk data using doubly robust outcome weighted learning with bi-level variable selection.

Yizeng He, Soyoung Kim, Mi-Ok Kim, Wael Saber, Kwang Woo Ahn

Abstract read
In one paragraph

Article in Computational statistics & data analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yizeng HeDivision of Biostatistics, Medical College of Wisconsin, Milwaukee WI 53226, USA.
Soyoung KimDivision of Biostatistics, Medical College of Wisconsin, Milwaukee WI 53226, USA.
Mi-Ok KimDepartment of Epidemiology and Biostatistics, University of California, San Francisco CA 94143, USA.
Wael SaberDivision of Hematology and Oncology, Medical College of Wisconsin, Milwaukee WI 53226, USA.
Kwang Woo AhnDivision of Biostatistics, Medical College of Wisconsin, Milwaukee WI 53226, USA.

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
NCI NIH HHS U24 CA076518
6 · The paper itself

Abstract

The goal of the optimal treatment regime is maximizing treatment benefits via personalized treatment assignments based on the observed patient and treatment characteristics. Parametric regression-based outcome learning approaches require exploring complex interplay between the outcome and treatment assignments adjusting for the patient and treatment covariates, yet correctly specifying such relationships is challenging. Thus, a robust method against misspecified models is desirable in practice. Parsimonious models are also desired to pursue a concise interpretation and to avoid including spurious predictors of the outcome or treatment benefits. These issues have not been comprehensively addressed in the presence of competing risks. Recognizing that competing risks and group variables are frequently present, we propose a doubly robust estimation with adaptive

Indexed as

bi-level variable selectionCompeting risksoptimal treatment regimepersonalized medicine

Identifiers

PMID33994608
PMCPMC8117077

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.