Evidence map›Paper›PMID 33994604›Full record

ArticleJournal of the American Statistical Association2021

A semiparametric instrumental variable approach to optimal treatment regimes under endogeneity.

Yifan Cui, Eric Tchetgen Tchetgen

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Statistical Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 56 citations in OpenAlex.

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  11. Meta-analysis of individualized treatment rules via sign-coherency.Proceedings of machine learning research · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yifan CuiDepartment of Statistics, The Wharton School, University of Pennsylvania, Philadelphia, PA 19104.
Eric Tchetgen TchetgenDepartment of Statistics, The Wharton School, University of Pennsylvania, Philadelphia, PA 19104.
University of Pennsylvania · US

Funding

Next Generation Missing Data Methods in HIV ResearchR01AI127271 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI TCHETGEN TCHETGEN, ERIC JOEL · 2017 to 2021
$3.2M
Novel Designs and Methods to Remove Hidden Confounding Bias in Health SciencesR01AG065276 · NIA · UNIVERSITY OF PENNSYLVANIA · PI TCHETGEN TCHETGEN, ERIC JOEL · 2020 to 2024
$2.4M
Theory and methods for mediation and interactionR01CA222147 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI TCHETGEN TCHETGEN, ERIC JOEL, VANDERWEELE, TYLER · 2018 to 2022
$2.1M
NCI NIH HHS R01 CA222147NIAID NIH HHS R01 AI127271NIA NIH HHS R01 AG065276
6 · The paper itself

Abstract

There is a fast-growing literature on estimating optimal treatment regimes based on randomized trials or observational studies under a key identifying condition of no unmeasured confounding. Because confounding by unmeasured factors cannot generally be ruled out with certainty in observational studies or randomized trials subject to noncompliance, we propose a general instrumental variable approach to learning optimal treatment regimes under endogeneity. Specifically, we establish identification of both value function

Indexed as

Complier optimal regimesInstrumental variableOptimal treatment regimesPrecision medicineUnmeasured confounding

Identifiers

PMID33994604
PMCPMC8118566
OpenAlexW3043168695

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.