Evidence map›Paper›PMID 33994431›Full record

ArticleJournal of clinical and experimental hematopathology : JCEH2021

Necrotizing lymphadenitis may be induced by overexpression of Toll-like receptor7 (TLR7) caused by reduced TLR9 transport in plasmacytoid dendritic cells (PDCs).

Shigeyuki Asano, Hiroko Sato, Kikuo Mori, Kazuki Yamazaki, Hiroyuki Naito, Hoshiro Suzuki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental hematopathology : JCEH, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Suggestive characteristic change of CD123Journal of clinical and experimental hematopathology : JCEH · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shigeyuki AsanoPathology Center, Iwaki City Medical Center, Iwaki, Japan.
Hiroko SatoDepartment of Dentistry and Oral Surgery, Iwaki City Medical Center, Iwaki, Japan.
Kikuo MoriPathology Center, Iwaki City Medical Center, Iwaki, Japan.
Kazuki YamazakiPathology Center, Iwaki City Medical Center, Iwaki, Japan.
Hiroyuki NaitoDepartment of Dentistry and Oral Surgery, Iwaki City Medical Center, Iwaki, Japan.
Hoshiro SuzukiDepartment of Pediatrics, Iwaki City Medical Center, Iwaki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Necrotizing lymphadenitis (NEL) is a self-limited systemic disease exhibiting characteristic clinical features. The pathogenesis of the disease remains unclear, but it may be associated with viral infection. In lymph nodes affected by this disease, innumerable plasmacytoid dendritic cells produce interferon-α when triggered by certain viral stimuli. IFN-α presents antigens causing the transformation of CD8

Indexed as

AdolescentAdultChildChild, PreschoolDendritic CellsFemaleHumansLymphadenitisMaleMiddle AgedProtein TransportToll-Like Receptor 7Toll-Like Receptor 9Young AdultTLR7 protein, humanTLR9 protein, humanToll-Like Receptor 7Toll-Like Receptor 9necrotizing lymphadenitisplasmacytoid dendritic cellsTLR7TLR9UNC93B1

Identifiers

PMID33994431
PMCPMC8265496
OpenAlexW3163105335

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.