Evidence map›Paper›PMID 33994299›Full record

ReviewSeminars in cell & developmental biology2022

Sex differences in daily timekeeping and circadian clock circuits.

Deborah A M Joye, Jennifer A Evans

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Sex and gender differences in metabolic dysfunction-associated liver disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Review
  3. Article
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  13. Article
  14. Endocrine regulation of circadian rhythms.Npj biological timing and sleep · 2025
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Deborah A M JoyeMarquette University, Department of Biomedical Sciences, Milwaukee, WI, USA.
Jennifer A EvansMarquette University, Department of Biomedical Sciences, Milwaukee, WI, USA. Electronic address: jennifer.evans@marquette.edu.
Marquette University · US

Funding

Inhibitory feedback mechanisms that couple circadian clock neurons in mammalsR01NS091234 · NINDS · MARQUETTE UNIVERSITY · PI EVANS, JENNIFER ANNE · 2015 to 2019
$1.7M
NINDS NIH HHS R01 NS091234
6 · The paper itself

Abstract

The circadian system regulates behavior and physiology in many ways important for health. Circadian rhythms are expressed by nearly every cell in the body, and this large system is coordinated by a central clock in the suprachiasmatic nucleus (SCN). Sex differences in daily rhythms are evident in humans and understanding how circadian function is modulated by biological sex is an important goal. This review highlights work examining effects of sex and gonadal hormones on daily rhythms, with a focus on behavior and SCN circuitry in animal models commonly used in pre-clinical studies. Many questions remain in this area of the field, which would benefit from further work investigating this topic.

Indexed as

Circadian ClocksAnimalsCircadian RhythmFemaleMaleSex CharacteristicsSuprachiasmatic NucleusAndrogenCircadian rhythmEstrogenGonadal hormoneSex chromosomeSex differenceSuprachiasmatic nucleus

Identifiers

PMID33994299
PMCPMC8589873
OpenAlexW3162844402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.