Evidence map›Paper›PMID 33994111›Full record

ArticleTrends in immunology2021

The impact of age-related hypomethylated DNA on immune signaling upon cellular demise.

Lauren A Urban, Annie Trinh, Eric Pearlman, Albert Siryaporn, Timothy L Downing

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. γδ T cells: origin and fate, subsets, diseases and immunotherapy.Signal transduction and targeted therapy · 2023
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lauren A UrbanDepartment of Microbiology and Molecular Genetics, University of California-Irvine, Irvine, CA 92697, USA; The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California-Irvine, Irvine, CA 92697, USA.
Annie TrinhDepartment of Microbiology and Molecular Genetics, University of California-Irvine, Irvine, CA 92697, USA; The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California-Irvine, Irvine, CA 92697, USA.
Eric PearlmanInstitute for Immunology, University of California-Irvine, Irvine, CA 92697, USA; Department of Ophthalmology, University of California-Irvine, Irvine, CA 92697, USA; Department of Physiology and Biophysics, University of California-Irvine, Irvine, CA 92697, USA.
Albert SiryapornDepartment of Physics and Astronomy, University of California-Irvine, Irvine, CA 92697, USA; Department of Molecular Biology and Biochemistry, University of California-Irvine, Irvine, CA 92697, USA.
Timothy L DowningDepartment of Microbiology and Molecular Genetics, University of California-Irvine, Irvine, CA 92697, USA; The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California-Irvine, Irvine, CA 92697, USA; Department of Biomedical Engineering, University of California-Irvine, Irvine, CA 92697, USA. Electronic address: tim.downing@uci.edutim.downing@uci.edu.

Funding

Spatial epigenomics: A new framework for overcoming mechanical heterogeneity in solid tumorsDP2CA250382 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI DOWNING, TIMOTHY LAMONT · 2019 to 2019
$2.4M
Epigenetic regulation of macrophage response to biomaterial implantsR21EB027840 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI DOWNING, TIMOTHY LAMONT, LIU, WENDY · 2019 to 2020
$398k
NCI NIH HHS DP2 CA250382NIBIB NIH HHS R21 EB027840
6 · The paper itself

Abstract

Aging is associated with decreased antigen-specific immunity and increased chronic inflammation. While DNA-sensing pathways might be involved, the molecular factors underlying these age-related aberrancies in immune signaling are unclear. Here, we consider the potential role of aging-induced hypomethylated DNA as a putative stimulant of age-associated inflammation.

Indexed as

AgingSignal TransductionDNAHumansInflammationDNA

Identifiers

PMID33994111
PMCPMC9650629

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.