Evidence map›Paper›PMID 33993998›Full record

ArticleBiological psychiatry2022

Distinct Roles of the Human Subthalamic Nucleus and Dorsal Pallidum in Parkinson's Disease Impulsivity.

Robert S Eisinger, Jackson N Cagle, Jose D Alcantara, Enrico Opri, Stephanie Cernera, Anh Le, Elena M Torres Ponce, Joseph Lanese, Brawn Nelson, Janine Lopes and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Robert S EisingerDepartment of Neuroscience, University of Florida, Gainesville, Florida. Electronic address: eisinger@ufl.edu.
Jackson N CagleJ. Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, Florida.
Jose D AlcantaraJ. Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, Florida.
Enrico OpriJ. Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, Florida.
Stephanie CerneraJ. Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, Florida.
Anh LeDepartment of Neuroscience, University of Florida, Gainesville, Florida.
Elena M Torres PonceDepartment of Neuroscience, University of Florida, Gainesville, Florida.
Joseph LaneseDepartment of Neuroscience, University of Florida, Gainesville, Florida.
Brawn NelsonDepartment of Neuroscience, University of Florida, Gainesville, Florida.
Janine LopesDepartment of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida.
Christopher HundleyDepartment of Neuroscience, University of Florida, Gainesville, Florida.
Tasmeah RavyDepartment of Neuroscience, University of Florida, Gainesville, Florida.
Samuel S WuDepartment of Biostatistics, University of Florida, Gainesville, Florida.
Kelly D FooteDepartment of Neurosurgery, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida.
Michael S OkunDepartment of Neuroscience, University of Florida, Gainesville, Florida; Department of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida; Department of Neurosurgery, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida.
Aysegul GunduzDepartment of Neuroscience, University of Florida, Gainesville, Florida; J. Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, Florida.
University of Florida · US

Funding

Together: Transforming and Translating Discovery to Improve HealthTL1TR001428 · NCATS · UNIVERSITY OF FLORIDA · PI MCCORMACK, WAYNE T. · 2015 to 2023
$3.9M
Mobile Decision Support System for Nurse Management of Neuromodulation TherapyR01NR014852 · NINR · UNIVERSITY OF UTAH · PI BUTSON, CHRISTOPHER R, OKUN, MICHAEL S · 2015 to 2019
$2.9M
Local field potentials reveal reward processing and impulse control disorders in Parkinson’s diseaseF30NS111841 · NINDS · UNIVERSITY OF FLORIDA · PI EISINGER, ROBERT STEPHEN · 2019 to 2022
$124k
NCATS NIH HHS TL1 TR001428NINDS NIH HHS F30 NS111841NINR NIH HHS R01 NR014852
6 · The paper itself

Abstract

backgroundImpulsivity and impulse control disorders are common in Parkinson's disease and lead to increased morbidity and reduced quality of life. Impulsivity is thought to arise from aberrant reward processing and inhibitory control, but it is unclear why deep brain stimulation of either the subthalamic nucleus (STN) or globus pallidus internus (GPi) affects levels of impulsivity. Our aim was to assess the role of the STN and GPi in impulsivity using invasive local field potential (LFP) recordings from deep brain stimulation electrodes.

methodsWe measured LFPs during a simple rewarding Go/NoGo paradigm in 39 female and male human patients with Parkinson's disease manifesting variable amounts of impulsivity who were undergoing unilateral deep brain stimulation of either the STN (18 nuclei) or GPi (28 nuclei). We identified reward-specific LFP event-related potentials and correlated them to impulsivity severity.

resultsLFPs in both structures modulated during reward-specific Go and NoGo stimulus evaluation, reward feedback, and loss feedback. Motor and limbic functions were anatomically separable in the GPi but not in the STN. Across participants, LFP reward processing responses in the STN and GPi uniquely depended on the severity of impulsivity.

conclusionsThis study establishes LFP correlates of impulsivity within the STN and GPi regions. We propose a model for basal ganglia reward processing that includes the bottom-up role of the GPi in reward salience and the top-down role of the STN in cognitive control.

Indexed as

Deep Brain StimulationParkinson DiseaseSubthalamic NucleusFemaleGlobus PallidusHumansImpulsive BehaviorMaleQuality of LifeDeep brain stimulationGlobus pallidusImpulse control disorderImpulsivityLocal field potentialsParkinson’s diseaseReward processingSubthalamic nucleus

Identifiers

PMID33993998
PMCPMC8419208
OpenAlexW3135650685

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.