Can anaesthetic technique influence cancer outcome? The next steps….

Donal J Buggy, Bernhard Riedel, Daniel I Sessler

Abstract readEditorialComment

In one paragraph

Article in British journal of anaesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed, 1 pooled it

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

Anesthesia-related intervention for long-term survival and cancer recurrence following breast cancer surgery: A systematic review of prospective studies.PloS one · 2023
Pooled it
Cluster analysis of global research hotspots and thematic evolution in breast cancer and general anesthesia a bibliometric study from 1985 to 2024.Discover oncology · 2026
Article
The effects of anaesthesia and analgesia on short- and long-term outcomes following colorectal cancer surgery: Protocol for an international, pragmatic, cohort study (ENCORE∗).European journal of anaesthesiology and intensive care · 2024
Article
The influence of anaesthesia on cancer growth.Radiology and oncology · 2024
Review
Anaesthetic Techniques and Strategies: Do They Influence Oncological Outcomes?Current oncology (Toronto, Ont.) · 2023
Review
Anesthetics and Long Term Cancer Outcomes: May Epigenetics Be the Key for Pancreatic Cancer?Medicina (Kaunas, Lithuania) · 2022
Review

4 · The record

Corrections and comments

Comment on
Comparison between epidural and intravenous analgesia effects on disease-free survival after colorectal cancer surgery: a randomised multicentre controlled trial.2021

5 · Who and what money

Authors and funding

3 authors.

Donal J BuggyMater University Hospital, School of Medicine, University College Dublin, Dublin, Ireland; Outcomes Research Consortium, Cleveland, OH, USA. Electronic address: donal.buggy@ucd.ie.

Bernhard RiedelPeter MacCallum Cancer Centre, Sir Peter MacCallum Department of Oncology and the Department of Critical Care, University of Melbourne, Melbourne, Australia.

Daniel I SesslerOutcomes Research Consortium, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anesthesia, ConductionAnestheticsNeoplasmsHumansAnestheticsanalgesiacancer recurrencedisease-free survivalepidural anaesthesiaopioidvolatile anaesthesia

Identifiers

PMID33993953

DOI10.1016/j.bja.2021.04.005

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.