Evidence map›Paper›PMID 33993918›Full record

ReviewAdvances in immunology2021

Thymoproteasome optimizes positive selection of CD8

Izumi Ohigashi, Yousuke Takahama

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. The thymoproteasome in shaping the CD8Current opinion in immunology · 2023
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Izumi OhigashiDivision of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima, Tokushima, Japan.
Yousuke TakahamaThymus Biology Section, Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States. Electronic address: yousuke.takahama@nih.gov.
National Cancer Institute · USTokushima University · JP

Funding

Thymus biologyZIABC011806 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TAKAHAMA, YOUSUKE · 2018 to 2025
$13.5M
Intramural NIH HHS ZIA BC011806
6 · The paper itself

Abstract

Functionally competent and self-tolerant T cell repertoire is shaped through positive and negative selection in the cortical and medullary microenvironments of the thymus. The thymoproteasome specifically expressed in the cortical thymic epithelium is essential for the optimal generation of CD8

Indexed as

CD8-Positive T-LymphocytesProteasome Endopeptidase ComplexApoptosisEpithelial CellsHistocompatibility Antigens Class IHumansThymus GlandHistocompatibility Antigens Class IProteasome Endopeptidase ComplexNegative selectionPositive selectionT cell repertoireT cell selectionThymic cortexThymic medullaThymoproteasomeThymusβ5t

Identifiers

PMID33993918
PMCPMC8237917
OpenAlexW3161536803

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.