Evidence map›Paper›PMID 33993873›Full record

ArticleBMC medical research methodology2021

Methodology of the DCCSS later fatigue study: a model to investigate chronic fatigue in long-term survivors of childhood cancer.

Adriaan Penson, Sylvia van Deuren, Ewald Bronkhorst, Ellen Keizer, Tom Heskes, Marieke J H Coenen, Judith G M Rosmalen, Wim J E Tissing, Helena J H van der Pal, Andrica C H de Vries and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical research methodology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 8 institutions in 1 country.

Adriaan PensonDepartment of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands. adriaan.penson@radboudumc.nl.
Sylvia van DeurenDepartment of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.
Ewald BronkhorstDepartment of Dentistry, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Ellen KeizerDepartment of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.
Tom HeskesInstitute for Computing and Information Sciences, Radboud University, Nijmegen, The Netherlands.
Marieke J H CoenenDepartment of Human Genetics, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Judith G M RosmalenInterdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Wim J E TissingPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Helena J H van der PalPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Andrica C H de VriesDepartment of Pediatric Oncology, Erasmus Medical Center, Rotterdam, The Netherlands.
Marry M van den Heuvel-EibrinkPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Sebastian NeggersPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Birgitta A B VersluysPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Marloes LouwerensDepartment of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Margriet van der Heiden-van der LooDutch Childhood Oncology Group - Late Effects after Childhood Cancer (LATER) registry, Utrecht, The Netherlands.
Saskia M F PluijmPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Martha GrootenhuisDepartment of Psychology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Nicole BlijlevensDepartment of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.
Leontien C M KremerPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Eline van Dulmen-den BroederDepartment of Pediatric Oncology/Hematology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Hans KnoopDepartment of Medical Psychology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Public health research institute, Amsterdam, Netherlands.
Jacqueline LoonenDepartment of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.
Princess Máxima Center · NLRadboud University Medical Center · NLRadboud University Nijmegen · NLUniversity of Amsterdam · NLUniversity of Groningen · NLErasmus MC · NLLeiden University Medical Center · NLStichting Kinderoncologie Nederland · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA debilitating late effect for childhood cancer survivors (CCS) is cancer-related fatigue (CRF). Little is known about the prevalence and risk factors of fatigue in this population. Here we describe the methodology of the Dutch Childhood Cancer Survivor Late Effect Study on fatigue (DCCSS LATER fatigue study). The aim of the DCCSS LATER fatigue study is to examine the prevalence of and factors associated with CRF, proposing a model which discerns predisposing, triggering, maintaining and moderating factors. Triggering factors are related to the cancer diagnosis and treatment during childhood and are thought to trigger fatigue symptoms. Maintaining factors are daily life- and psychosocial factors which may perpetuate fatigue once triggered. Moderating factors might influence the way fatigue symptoms express in individuals. Predisposing factors already existed before the diagnosis, such as genetic factors, and are thought to increase the vulnerability to develop fatigue. Methodology of the participant inclusion, data collection and planned analyses of the DCCSS LATER fatigue study are presented.

resultsData of 1955 CCS and 455 siblings was collected. Analysis of the data is planned and we aim to start reporting the first results in 2022.

conclusionThe DCCSS LATER fatigue study will provide information on the epidemiology of CRF and investigate the role of a broad range of associated factors in CCS. Insight in associated factors for fatigue in survivors experiencing severe and persistent fatigue may help identify individuals at risk for developing CRF and may aid in the development of interventions.

Indexed as

Cancer SurvivorsFatigue Syndrome, ChronicNeoplasmsChildHumansQuality of LifeRisk FactorsSurvivorsAssociated factorsCancer related fatigueChildhood Cancer survivorsChronic fatigueMethodologyMultivariable fatigue model

Identifiers

PMID33993873
PMCPMC8127233
OpenAlexW3161237948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.