Evidence map›Paper›PMID 33993833›Full record

ArticleRenal failure2021

Association between serum elastin-derived peptides and abdominal aortic calcification in peritoneal dialysis patients: a cross-sectional study.

Shizhu Zhao, Jingyuan Cao, Jianzhong Li, Xiaochun Yang, Peiyang Cao, Jingjing Lan, Guoyuan Lu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Shizhu ZhaoDepartment of Nephrology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jingyuan CaoDepartment of Nephrology, Taizhou People's hospital, The Fifth Affiliated Hospital of Nantong University, Taizhou, China.
Jianzhong LiDepartment of Nephrology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Xiaochun YangDepartment of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Peiyang CaoDepartment of Nephrology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jingjing LanDepartment of Nephology, Wuxi Traditional Chinese Medicine Hospital, Wuxi, China.
Guoyuan LuDepartment of Nephrology, The First Affiliated Hospital of Soochow University, Suzhou, China.
First Affiliated Hospital of Soochow University · CNNantong University · CNSecond Affiliated Hospital of Soochow University · CNShanghai Traditional Chinese Medicine Hospital · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeritoneal dialysis (PD) patients experience accelerated arterial aging, which is characterized by elastin degradation. Elastin-derived peptides (EDPs) are direct products of elastin fragmentation. This study tried to explore the association between serum EDPs and abdominal aortic calcification (AAC) in PD patients.

methodsSerum levels of EDPs were analyzed in 126 eligible PD patients and 30 controls. PD patients were grouped according to the annularity of AAC evaluated by an abdominal computed tomography (CT) scan. Serum EDPs were analyzed in relation to the presence of AAC or severe AAC in PD patients by logistic regression analysis.

resultsSerum EDPs in PD patients were significantly higher than age-matched controls. In 126 PD patients, higher EDPs was associated with greater risk of present AAC (OR = 1.056, 95%CI 1.010-1.103) and severe AAC (OR = 1.062, 95%CI 1.004-1.123). A combination of EDPs substantially improved the accuracy of diagnostic performance for AAC and severe AAC.

conclusionsEDPs can predict the presence and extent of AAC in PD patients, indicating its possible role to recognize PD patients at risk for AAC and severe AAC.

Indexed as

Peritoneal DialysisAdultAorta, AbdominalCase-Control StudiesCross-Sectional StudiesElastinFemaleHumansLogistic ModelsMaleMiddle AgedPeptide FragmentsPredictive Value of TestsRisk FactorsTomography, X-Ray ComputedVascular CalcificationElastinPeptide Fragmentsabdominal aortic calcificationelastinelastin-derived peptidesPeritoneal dialysis

Identifiers

PMID33993833
PMCPMC8143601
OpenAlexW3161445104

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.