Evidence map›Paper›PMID 33993796›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

Acute micro-thrombosis after subarachnoid hemorrhage: A new therapeutic target?

Fenghui Ye, Richard F Keep, Ya Hua, Hugh Jl Garton, Guohua Xi

Open access · greenAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Fenghui YeDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Richard F KeepDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Ya HuaDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Hugh Jl GartonDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Guohua XiDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · US

Funding

Experimental Cerebral Hemorrhage: Mechanisms and TherapiesR35NS116786 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, GUOHUA · 2020 to 2024
$5.2M
Early hematoma lysis and hemoglobin toxicity in intracerebral hemorrhageR01NS106746 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KEEP, RICHARD F · 2018 to 2022
$2.5M
Targeting CD47 to aid in clearing intracerebral hemorrhagesR01NS096917 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUA, YA, XI, GUOHUA · 2016 to 2020
$1.7M
Peroxiredoxin-2 and Intracerebral Hemorrhage-Induced Brain InjuryR21NS112394 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUA, YA · 2019 to 2019
$429k
NINDS NIH HHS R01 NS096917NINDS NIH HHS R01 NS106746NINDS NIH HHS R21 NS112394NINDS NIH HHS R35 NS116786
6 · The paper itself

Abstract

Microthrombi formation in the brain following subarachnoid hemorrhage (SAH) has been recognized and suspected to contribute to cerebral ischemia. A recent study found that ultra-early cerebral micro-thrombosis occured four hours after experimental SAH. The number of thrombotic microvessels correlated with brain-blood barrier disruption and neuronal injury. If acute cerebral micro-thrombi also occur in humans, is it time to develop a therapy with systemic thrombolysis for SAH patients?

Indexed as

AnimalsDisease Models, AnimalHumansMiceSubarachnoid HemorrhageThrombosismicrothrombiMRISubarachnoid hemorrhagethrombolysis

Identifiers

PMID33993796
PMCPMC8393286
OpenAlexW3161683198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.