Evidence map›Paper›PMID 33993718›Full record

ArticleCirculation2021

Impact of Socioeconomic Status, Race and Ethnicity, and Geography on Prenatal Detection of Hypoplastic Left Heart Syndrome and Transposition of the Great Arteries.

Anita Krishnan, Marni B Jacobs, Shaine A Morris, Shabnam Peyvandi, Aarti H Bhat, Anjali Chelliah, Joanne S Chiu, Bettina F Cuneo, Grace Freire, Lisa K Hornberger and 19 more

Abstract readMulticenter Study
In one paragraph

Article in Circulation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Impact of socioeconomic status and remoteness of residence on pregnancy outcome in major congenital heart disease: mediation analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
    Article
  5. Article
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  7. [Factors influencing pregnancy decision-making among parents of fetuses with congenital heart disease].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
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  10. Review
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  15. Drivers of care and outcomes for people facing fetal conditions in the United States: a conceptual framework.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Review
  16. A Novel Prenatal Pipeline for Three-Dimensional Hemodynamic Modeling of the Fetal Aorta.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Anita KrishnanDivisions of Cardiology (A.K., M.T.D.), Children's National Hospital, Washington, DC.
Marni B JacobsBiostatistics (M.B.J.), Children's National Hospital, Washington, DC.
Shaine A MorrisDivision of Pediatric Cardiology, Baylor College of Medicine, Houston, TX (S.A.M., K.N.L.).
Shabnam PeyvandiDivision of Cardiology, Department of Pediatrics, University of California, San Francisco (S.P.).
Aarti H BhatDivision of Cardiology, Seattle Children's Hospital, University of Washington (A.H.B.).
Anjali ChelliahDivision of Pediatric Cardiology, Columbia University Irving Medical Center, New York (A.C.).
Joanne S ChiuDivision of Pediatric Cardiology, Johns Hopkins University, Baltimore, MD (J.S.C., S.K.).
Bettina F CuneoDivision of Cardiology, Children's Hospital of Colorado/University of Colorado, Aurora (B.F.C., L.H.).
Grace FreireDivision of Cardiology, Johns Hopkins University All Children's Hospital, St. Petersburg, FL (G.F.).
Lisa K HornbergerDivision of Pediatric Cardiology, University of Alberta, Edmonton, Canada (L.K.H., A.M.).
Lisa HowleyDivision of Cardiology, Children's Hospital of Colorado/University of Colorado, Aurora (B.F.C., L.H.).
Nazia HusainDivision of Cardiology, Ann and Robert H. Lurie Children's Hospital of Chicago, IL (N.H.).
Catherine IkembaDivision of Cardiology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (C.I., K.W.).
Ann Kavanaugh-McHughDivision of Pediatric Cardiology, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN (A.K.-M.).
Shelby KuttyDivision of Pediatric Cardiology, Johns Hopkins University, Baltimore, MD (J.S.C., S.K.).
Caroline LeeDivision of Cardiology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO (C.L.).
Keila N LopezDivision of Pediatric Cardiology, Baylor College of Medicine, Houston, TX (S.A.M., K.N.L.).
Angela McBrienDivision of Pediatric Cardiology, University of Alberta, Edmonton, Canada (L.K.H., A.M.).
Erik C MichelfelderEmory University School of Medicine, Children's Healthcare of Atlanta/Sibley Heart Center, GA (E.C.M.).
Nelangi M PintoDivision of Pediatric Cardiology, University of Utah, Salt Lake City (N.M.P.).
Rachel SchwartzDivision of Cardiology, Boston Children's Hospital, MA (R.S., W.T.).
Kenan W D SternDivision of Pediatric Cardiology, Icahn School of Medicine at Mount Sinai, Kravis Children's Hospital, New York (K.W.D.S.).
Carolyn TaylorDivision of Pediatric Cardiology, Medical University of South Carolina, Charleston (C.T.).
Varsha ThakurDivision of Cardiology, University of Toronto, Ontario, Canada (V.T.).
Wayne TworetzkyDivision of Cardiology, Boston Children's Hospital, MA (R.S., W.T.).
Carol Wittlieb-WeberDivision of Pediatric Cardiology, University of Rochester, NY (C.W.-W.).
Kris WolduDivision of Cardiology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (C.I., K.W.).
Mary T DonofrioDivisions of Cardiology (A.K., M.T.D.), Children's National Hospital, Washington, DC.
Fetal Heart Society

Funding

WirelessTechnology Assisted Weight Management in Pre-Diabetic Adolescents...P20MD000198 · NIMHD · HOWARD UNIVERSITY · PI JENKINS, RENEE R. · 2002 to 2016
$17.2M
NIMHD NIH HHS P20 MD000198
6 · The paper itself

Abstract

backgroundPrenatal detection (PND) has benefits for infants with hypoplastic left heart syndrome (HLHS) and transposition of the great arteries (TGA), but associations between sociodemographic and geographic factors with PND have not been sufficiently explored. This study evaluated whether socioeconomic quartile (SEQ), public insurance, race and ethnicity, rural residence, and distance of residence (distance and driving time from a cardiac surgical center) are associated with the PND or timing of PND, with a secondary aim to analyze differences between the United States and Canada.

methodsIn this retrospective cohort study, fetuses and infants <2 months of age with HLHS or TGA admitted between 2012 and 2016 to participating Fetal Heart Society Research Collaborative institutions in the United States and Canada were included. SEQ, rural residence, and distance of residence were derived using maternal census tract from the maternal address at first visit. Subjects were assigned a SEQ

resultsData on 1862 subjects (HLHS: n=1171, 92% PND; TGA: n=691, 58% PND) were submitted by 21 centers (19 in the United States). In the United States, lower SEQ was associated with lower PND in HLHS and TGA, with the strongest association in the lower SEQ of pregnancies with fetal TGA (quartile 1, 0.78 [95% CI, 0.64-0.85], quartile 2, 0.77 [95% CI, 0.64-0.93], quartile 3, 0.83 [95% CI, 0.69-1.00], quartile 4, reference). Hispanic ethnicity (relative risk, 0.85 [95% CI, 0.72-0.99]) and rural residence (relative risk, 0.78 [95% CI, 0.64-0.95]) were also associated with lower PND in TGA. Lower SEQ was associated with later PND overall; in the United States, rural residence and public insurance were also associated with later PND.

conclusionsWe demonstrate that lower SEQ, Hispanic ethnicity, and rural residence are associated with decreased PND for TGA, with lower SEQ also being associated with decreased PND for HLHS. Future work to increase PND should be considered in these specific populations.

Indexed as

Cohort StudiesEthnicityFemaleGeographyHumansHypoplastic Left Heart SyndromeMaleRacial GroupsRetrospective StudiesSocial ClassTransposition of Great Vesselscongenital heart diseasefetal developmentsocial determinants of health

Identifiers

PMID33993718
PMCPMC8162295

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.