Evidence map›Paper›PMID 33993642›Full record

ReviewJournal of diabetes investigation2021

β-Cell failure in diabetes: Common susceptibility and mechanisms shared between type 1 and type 2 diabetes.

Hiroshi Ikegami, Naru Babaya, Shinsuke Noso

Abstract readReview
In one paragraph

Review in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Exploring the Association ofBiomolecules · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Effect ofWorld journal of diabetes · 2025
    Article
  14. Review
  15. Article
  16. Article
  17. Genetics of type-1 diabetes.Diabetology international · 2024
    Review
  18. Review
  19. Review
  20. Scaling Insulin-Producing Cells by Multiple Strategies.Endocrinology and metabolism (Seoul, Korea) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hiroshi IkegamiDepartment of Endocrinology, Metabolism and Diabetes, Faculty of Medicine, Kindai University, Osaka-sayama, Osaka, Japan.ORCID https://orcid.org/0000-0001-8808-4605
Naru BabayaDepartment of Endocrinology, Metabolism and Diabetes, Faculty of Medicine, Kindai University, Osaka-sayama, Osaka, Japan.ORCID https://orcid.org/0000-0003-2466-1228
Shinsuke NosoDepartment of Endocrinology, Metabolism and Diabetes, Faculty of Medicine, Kindai University, Osaka-sayama, Osaka, Japan.ORCID https://orcid.org/0000-0002-0943-8450

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus is etiologically classified into type 1, type 2 and other types of diabetes. Despite distinct etiologies and pathogenesis of these subtypes, many studies have suggested the presence of shared susceptibilities and underlying mechanisms in β-cell failure among different types of diabetes. Understanding these susceptibilities and mechanisms can help in the development of therapeutic strategies regardless of the diabetes subtype. In this review, we discuss recent evidence indicating the shared genetic susceptibilities and common molecular mechanisms between type 1, type 2 and other types of diabetes, and highlight the future prospects as well.

Indexed as

ApoptosisEndoplasmic Reticulum StressOxidative StressAnimalsDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2HumansInsulin-Secreting CellsEndoplasmic reticulum stressOxidative stressβ-Cell failure

Identifiers

PMID33993642
PMCPMC8409822

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.