Evidence map›Paper›PMID 33993618›Full record

ArticleOral diseases2023

Validation of healthcare professional proxy-reported children's International Mucositis Evaluation Scale.

Nathaniel S Treister, Michael Nieder, Christina Baggott, Ellen Olson, Tammy Lo, Xichen Jin, Yun Gao, Lu Chen, Ha Dang, Lillian Sung

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Oral diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06623305 (Photobiomodulation Therapy for the Prevention of Mucositis in Pediatric Oncology Patients), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06623305 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Photobiomodulation Therapy for the Prevention of Mucositis in Pediatric Oncology Patients

TypeinterventionalSponsorMedical College of WisconsinRan2026 to 2027Enrolled50ConditionsMucositis OralArmsPhotobiomodulation for prevention arm, Photobiomodulation for exploratory arm
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
  3. Pain Assessment Tools for Infants, Children, and Adolescents With Cancer: A Scoping Review.Pediatrics international : official journal of the Japan Pediatric Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 10 institutions in 3 countries.

Nathaniel S TreisterDivision of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA, USA.ORCID https://orcid.org/0000-0002-5596-7222
Michael NiederDepartment of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Christina BaggottPediatric Hematology-Oncology, Stanford Medical Center, Stanford, CA, USA.
Ellen OlsonChildren's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Atlanta, GA, USA.
Tammy LoDepartment of Research and Evaluation, Kaiser Permanente, Pasadena, CA, USA.
Xichen JinData Operations, Global Drug Development, Novartis, Shanghai, China.
Yun GaoChildren's Oncology Group, Monrovia, CA, USA.
Lu ChenDivision of Biostatistics, City of Hope, Duarte, CA, USA.
Ha DangDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Lillian SungDivision of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
Aflac (United States) · USBrigham and Women's Hospital · USChildren's Oncology Group · USCity of Hope · USHospital for Sick Children · CAKaiser Permanente · USMoffitt Cancer Center · USNovartis (China) · CNStanford Medicine · USUniversity of Southern California · US

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
Children's Oncology Group Statistics &Data Center GrantU10CA098413 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ANDERSON, JAMES R · 2003 to 2013
$67.5M
National Cancer InstituteNCI NIH HHS U10 CA098413NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899NCTN Operations Center Grant U10CA180886NCTN Statistics & Data Center U10CA180899Statistics & Data Center Grant U10CA098413St. Baldrick's FoundationThe Children's Oncology Group Chair's Grant U10CA98543-08
6 · The paper itself

Abstract

objectiveThe objective was to describe the reliability and validity of the healthcare professional proxy-report version of the Children's International Mucositis Evaluation Scale (ChIMES).

methodsWe included pediatric patients who were between 4 and 21 years of age and scheduled to undergo hematopoietic cell transplantation. Mucositis was evaluated by trained healthcare professionals who scored ChIMES, the World Health Organization oral toxicity scale, mouth, and throat pain visual analogue scale, National Cancer Institute-Common Terminology Criteria and the Oral Mucositis Daily Questionnaire. Measures were completed daily and evaluated on days 7-17 post-stem cell infusion for this analysis. Psychometric properties examined were internal consistency, test-retest reliability (days 13 and 14), and convergent construct validity.

resultsThere were 192 participants included. Cronbach's alpha was 0.90 for ChIMES Total Score and 0.93 for ChIMES Percentage Score. Test-retest reliability were as follows: intraclass correlation coefficient (ICC) 0.82 (95% confidence interval (CI) 0.77-0.85) for ChIMES Total Score and ICC 0.82 (95% CI 0.77-0.86) for ChIMES Percentage Score. In terms of construct validation, all correlations between measures met or exceeded those hypothesized (all p < 0.05).

conclusionsThe healthcare professional proxy-report version of ChIMES is reliable and valid for children and adolescents undergoing hematopoietic cell transplantation.

Indexed as

MucositisStomatitisAdolescentChildDelivery of Health CareHumansPsychometricsReproducibility of ResultsSurveys and Questionnairesadolescentbone marrow transplantationchildhealth personnelmucositisproxysurveys and questionnaires

Identifiers

PMID33993618
PMCPMC9308945
OpenAlexW3161367897

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.