Evidence map›Paper›PMID 33993461›Full record

ArticleInterdisciplinary sciences, computational life sciences2021

TUPDB: Target-Unrelated Peptide Data Bank.

Bifang He, Shanshan Yang, Jinjin Long, Xue Chen, Qianyue Zhang, Hui Gao, Heng Chen, Jian Huang

Abstract read
PubMed Publisher
In one paragraph

Article in Interdisciplinary sciences, computational life sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Bifang HeSchool of Medicine, Guizhou University, Guiyang, 550025, China. bfhe@gzu.edu.cn.
Shanshan YangSchool of Medicine, Guizhou University, Guiyang, 550025, China.
Jinjin LongSchool of Medicine, Guizhou University, Guiyang, 550025, China.
Xue ChenSchool of Medicine, Guizhou University, Guiyang, 550025, China.
Qianyue ZhangSchool of Medicine, Guizhou University, Guiyang, 550025, China.
Hui GaoSchool of Computer Science and Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Heng ChenSchool of Medicine, Guizhou University, Guiyang, 550025, China. hchen13@gzu.edu.cn.
Jian HuangCenter for Informational Biology, University of Electronic Science and Technology of China, Chengdu, 611731, China. hj@uestc.edu.cn.
Guizhou University · CNUniversity of Electronic Science and Technology of China · CN

Funding

China Postdoctoral Science Foundation 2019M653369China Postdoctoral Science Foundation 2019M660236Guizhou Science and Technology Department (2018)5781Guizhou Science and Technology Department [2020]1Y345Guizhou Science and Technology Department [2020]1Y407Guizhou University (2018)54Guizhou University (2018)55National Natural Science Foundation of China 61901129National Natural Science Foundation of China 61901130National Natural Science Foundation of China 62071099
6 · The paper itself

Abstract

The isolation of target-unrelated peptides (TUPs) through biopanning remains as a major problem of phage display selection experiments. These TUPs do not have any actual affinity toward targets of interest, which tend to be mistakenly identified as target-binding peptides. Therefore, an information portal for storing TUP data is urgently needed. Here, we present a TUP data bank (TUPDB), which is a comprehensive, manually curated database of approximately 73 experimentally verified TUPs and 1963 potential TUPs collected from TUPScan, the BDB database, and public research articles. The TUPScan tool has been integrated in TUPDB to facilitate TUP analysis. We believe that TUPDB can help identify and remove TUPs in future reports in the biopanning community. The database is of great importance to improving the quality of phage display-based epitope mapping and promoting the development of vaccines, diagnostics, and therapeutics. The TUPDB database is available at http://i.uestc.edu.cn/tupdb .

Indexed as

Peptide LibraryDatabases, ProteinHumansPeptide LibraryBiopanningDatabasePhage displayTarget-unrelated peptides (TUPs)TUPDB

Identifiers

PMID33993461
OpenAlexW3162482332

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.