Evidence map›Paper›PMID 33993340›Full record

ArticleHistochemistry and cell biology2021

Selective involution of thymic medulla by cyclosporine A with a decrease of mature thymic epithelia, XCR1

Yasushi Sawanobori, Yusuke Kitazawa, Hisashi Ueta, Kenjiro Matsuno, Nobuko Tokuda

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Histochemistry and cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yasushi SawanoboriDepartment of Anatomy, School of Medicine, Dokkyo Medical University, Tochigi, Japan. sawa@dokkyomed.ac.jp.ORCID http://orcid.org/0000-0001-6249-2133
Yusuke KitazawaDepartment of Anatomy, School of Medicine, Dokkyo Medical University, Tochigi, Japan.
Hisashi UetaDepartment of Anatomy, School of Medicine, Dokkyo Medical University, Tochigi, Japan.
Kenjiro MatsunoDepartment of Anatomy, School of Medicine, Dokkyo Medical University, Tochigi, Japan.
Nobuko TokudaDepartment of Anatomy, School of Medicine, Dokkyo Medical University, Tochigi, Japan.
Dokkyo Medical University · JPDokkyo University · JP

Funding

Dokkyo Medical University the annual research budgetJapan Society for the Promotion of Science JP26860138Promotion and Mutual Aid Corporation for Private Schools of Japan 2017 The Science Research Promotion Fund
6 · The paper itself

Abstract

Immunosuppressive drugs such as cyclosporine A (CSA) can disrupt thymic structure and functions, ultimately inducing syngeneic/autologous graft-versus-host disease together with involuted medullas. To elucidate the effects of CSA on the thymus more precisely, we analyzed the effects of CSA on the thymus and T cell system using rats. In addition to confirming the phenomena already reported, we newly found that the proportion of recent thymic emigrants also greatly decreased, suggesting impaired supply. Immunohistologically, the medullary thymic epithelial cells (mTECs) presented with a relative decrease in the subset with a competent phenotype and downregulation of class II major histocompatibility complex molecules. In control rats, thymic dendritic cells (DCs) comprised two subsets, XCR1

Indexed as

AnimalsCyclosporineDendritic CellsEpithelial CellsForkhead Transcription FactorsImmunohistochemistryImmunosuppressive AgentsInjections, SubcutaneousMaleOptical ImagingRatsRats, Inbred LewReceptors, ChemokineThymocytesThymus GlandT-Lymphocytes, RegulatoryCyclosporineForkhead Transcription FactorsFoxp3 protein, ratImmunosuppressive AgentsReceptors, ChemokineXCR1 protein, ratDendritic cellsImmunosuppressive drugRegulatory T cellsThymic epithelial cellsThymic structureThymus

Identifiers

PMID33993340
PMCPMC8397693
OpenAlexW3162876416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.