Evidence map›Paper›PMID 33993332›Full record

ArticleEuropean radiology2021

Non-contrast MRI of synovitis in the knee using quantitative DESS.

Jacob Thoenen, Kathryn J Stevens, Tom D Turmezei, Akshay Chaudhari, Lauren E Watkins, Emily J McWalter, Brian A Hargreaves, Garry E Gold, James W MacKay, Feliks Kogan

Open access · greenAbstract read
In one paragraph

Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

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  13. Imaging of Synovial Inflammation in Osteoarthritis, From theAJR. American journal of roentgenology · 2022
    Review
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  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Jacob ThoenenDepartment of Radiology, Stanford University, Stanford, CA, USA. jthoenen@stanford.edu.ORCID http://orcid.org/0000-0001-5348-3462
Kathryn J StevensDepartment of Radiology, Stanford University, Stanford, CA, USA.
Tom D TurmezeiDepartment of Radiology, Norfolk and Norwich University Hospital, Norwich, UK.
Akshay ChaudhariDepartment of Radiology, Stanford University, Stanford, CA, USA.
Lauren E WatkinsDepartment of Radiology, Stanford University, Stanford, CA, USA.
Emily J McWalterDepartment of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada.
Brian A HargreavesDepartment of Radiology, Stanford University, Stanford, CA, USA.
Garry E GoldDepartment of Radiology, Stanford University, Stanford, CA, USA.
James W MacKayDepartment of Radiology, University of Cambridge, Cambridge, UK.
Feliks KoganDepartment of Radiology, Stanford University, Stanford, CA, USA.
Stanford University · USNorfolk and Norwich University Hospital · GBStanford Medicine · USUniversity of East Anglia · GBUniversity of Saskatchewan · CA

Funding

Rapid MRI for Evaluation of OsteoarthritisR01EB002524 · NIBIB · STANFORD UNIVERSITY · PI Akshay Chaudhari, Garry E Gold · 2003 to 2026
$10.1M
Rapid Low-Cost Quantitative 3D MRI and Gait Assessment of the KneeR01AR077604 · NIAMS · STANFORD UNIVERSITY · PI HARGREAVES, BRIAN ANDREW · 2020 to 2024
$3.2M
Advanced MR Imaging of Early OsteoarthritisK24AR062068 · NIAMS · STANFORD UNIVERSITY · PI GOLD, GARRY E · 2012 to 2022
$1.7M
Quantitative Assessment of Early Metabolic and Biochemical Changes in OsteoarthritisR00EB022634 · NIBIB · STANFORD UNIVERSITY · PI KOGAN, FELIKS · 2019 to 2021
$730k
NIAMS NIH HHS K24 AR062068NIAMS NIH HHS R01 AR077604NIBIB NIH HHS R00 EB022634NIBIB NIH HHS R01 EB002524NIH HHS R00-EB022634NIH HHS R01-AR077604NIH HHS R01-EB002524NIH HHS R02-AR0063643NIH HHS R24-AR062068-07
6 · The paper itself

Abstract

objectivesTo determine whether synovitis graded by radiologists using hybrid quantitative double-echo in steady-state (qDESS) images can be utilized as a non-contrast approach to assess synovitis in the knee, compared against the reference standard of contrast-enhanced MRI (CE-MRI).

methodsTwenty-two knees (11 subjects) with moderate to severe osteoarthritis (OA) were scanned using CE-MRI, qDESS with a high diffusion weighting (qDESS

resultsGood agreement was seen between CE-MRI and both qDESS

conclusionsqDESS shows potential as an alternative MRI technique for assessing the severity of synovitis without the use of a gadolinium-based contrast agent. KEY POINTS: The use of the quantitative double-echo in steady-state (qDESS) sequence for synovitis assessment does not require the use of a gadolinium-based contrast agent. Preliminary results found that low diffusion-weighted qDESS (qDESS

Indexed as

Osteoarthritis, KneeSynovitisContrast MediaHumansKnee JointMagnetic Resonance ImagingSynovial MembraneContrast MediaGadoliniumKnee jointMagnetic resonance imagingOsteoarthritisSynovitis

Identifiers

PMID33993332
PMCPMC8591148
OpenAlexW3161957076

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.