SynthesisBreast (Edinburgh, Scotland)2021
Preoperative non-palpable breast lesion localization, innovative techniques and clinical outcomes in surgical practice: A systematic review and meta-analysis.
Synthesis in Breast (Edinburgh, Scotland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Trial
- Global research trends and thematic evolution of imaging-guided localization in breast cancer surgery: a bibliometric analysis.Gland surgery · 2026Article
- Specimen PET-CT Imaging for Intraoperative Margin Assessment in Early-Stage Breast Cancer: The BrIMA Nonrandomized Clinical Trial.JAMA surgery · 2026Article
- Digital twins for non-invasive tumor localization in breast-conserving surgery: a technical pilot study.Breast (Edinburgh, Scotland) · 2026Article
- Mammogram geometric projection localization (MaGPL) for surgical body-surface localization of nonpalpable breast calcifications.Gland surgery · 2026Article
- Bracketed Lumpectomy: A Comparison of Radiofrequency Identification Tag Localization to Wire Localization.Annals of surgical oncology · 2026Article
- Evolving Concepts and Contemporary Management of Early-Stage Breast Cancer: An Evidence-Based Approach to Grey Zones from a Comprehensive Breast Unit Part 1: Locoregional Therapy, Pathology, Radiology.European journal of breast health · 2026Article
- SCOUTCancers · 2025Article
- Diagnostic performance of ultrasound elastography in differentiating malignant from benign breast microcalcifications: a case-control study.BMC medical imaging · 2025Article
- Evaluation of Hologic LOCalizer™ RFID Tags for Preoperative Localization of Breast Lesions: A Single-Center Experience.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Magseed preoperative localization in non-palpable breast lesions: Our single-center Breast Unit experience.Journal of public health research · 2024Article
- Wirelessly Powered Visible Light-Emitting Implant for Surgical Guidance during Lumpectomy.Sensors (Basel, Switzerland) · 2024Article
- Breast-Conserving Surgery Guided with Magnetic Seeds vs. Wires: A Single-Institution Experience.Cancers · 2024Article
- Breast and axillary marking in the neoadjuvant setting: survey results from experts of the Brazilian society of mastology.Frontiers in oncology · 2024Article
- Evolution of localization methods for non-palpable breast lesions: a literature review from a translational medicine perspective.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2024Review
- Surgeon and Radiologist Evaluation of Electromagnetic Chip Localization for Benign and Malignant Breast Lesions.Annals of surgical oncology · 2023Article
- Characteristics of Breast Charcoal Granuloma: A Delayed Complication Following Tattoo Localization.Diagnostics (Basel, Switzerland) · 2023Article
- The Impact of an Electromagnetic Seed Localization Device Versus Wire Localization on Breast-Conserving Surgery: A Matched-Pair Analysis.Annals of surgical oncology · 2023Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pre-operative localization of non-palpable breast lesions with non-wired non-ionizing (NWNI) techniques may improve clinical outcomes as reoperation rate, cosmetic outcome and contribute to organizational aspects improvement in breast-conserving surgery (BCS). However only limited literature is available and clinical studies involving these forefront devices are often small and non-randomized. Furthermore, there is a lack of consensus on free margins and cosmetic outcomes definitions. The objective of the present meta-analysis was to determine the crude clinical outcomes reported for the NWNI techniques on BCS. A literature search was performed of PubMed, Embase and Scopus databases up to February 2021 in order to select all prospective or retrospective clinical trials on pre-operative breast lesion localization done with NWNI devices. All studies were assessed following the PRISMA recommendations. Continuous outcomes were described in averages corrected for sample size, while binomial outcomes were described using the weighted average proportion. Twenty-seven studies with a total of 2103 procedures were identified. The technique is consolidated, showing for both reflectors' positioning and localization nearly the 100% rate of success. The re-excision and clear margins rates were 14% (95% CI, 11-17%) and 87% (80-92%), respectively. Overall, positive margins rates were 12% (8-17%). In studies that compared NWNI and wire localization techniques, positive margin rate is lower for the first techniques (12%, 6-22% vs 17%, 12-23%) and re-excision rate is slightly higher using the latter (13%, 9-19% vs 16%, 13-18%). Pre-operative NWNI techniques are effective in the localization of non-palpable breast lesions and are promising in obtaining clear (or negative) margins minimizing the need for re-excision and improving the cosmetic outcomes. Randomized trials are needed to confirm these findings.
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