Evidence map›Paper›PMID 33991757›Full record

ArticleOral oncology2021

The role of age in treatment decisions for oral cavity squamous cell carcinoma: Analysis of the National Cancer Database.

Thomas F Barrett, Angela L Mazul, Katelyn O Stepan, C Burton Wood, Randall C Paniello, Jose P Zevallos, Sean Massa, Ryan S Jackson, Nicole C Schmitt, Joseph Zenga and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Association ofInternational journal of medical sciences · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Surgery Versus Radiotherapy in Older Adults with Oral Cavity Cancer: A Nationwide Comparative Effectiveness Study.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Thomas F BarrettDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Angela L MazulDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Katelyn O StepanDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA.
C Burton WoodDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Randall C PanielloDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Jose P ZevallosDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Sean MassaDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Ryan S JacksonDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Nicole C SchmittDepartment of Otolaryngology - Head and Neck Surgery, Emory School of Medicine, Atlanta, GA, USA.
Joseph ZengaDepartment of Otolaryngology - Head and Neck Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Stephen Y KangDepartment of Otolaryngology - Head and Neck Surgery, Wexner Medical Center at The Ohio State University, Columbus, OH, USA.
Patrik PipkornDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Jason T RichDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: richj@wustl.edu.
Sidharth V PuramDepartment of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: sidpuram@wustl.edu.
Washington University in St. Louis · USEmory Healthcare · USMedical College of Wisconsin · USThe Ohio State University Wexner Medical Center · US

Funding

DEVELOPMENT OF CLINICIAN/RESEARCHERS IN ACADEMIC ENTT32DC000022 · NIDCD · WASHINGTON UNIVERSITY · PI PICCIRILLO, JAY F. · 1989 to 2022
$5.6M
NIDCD NIH HHS T32 DC000022
6 · The paper itself

Abstract

backgroundThe number of elderly patients with oral squamous cell carcinoma (OCSCC) is increasing as the elderly population increases. Unfortunately, evidence to guide the management of these patients is lacking.

methodsPatients with OCSCC identified from the National Cancer Database (NCDB) were stratified into age-based cohorts. Demographics, comorbidities, and treatment patterns were analyzed. Patients were stratified into early stage (Stage I/II) and advanced stage (Stage III/IV) disease. The likelihood of receiving multimodality therapy by age was calculated using multinomial logistic regression for each stratum while controlling for potential confounders. Cox proportional hazard regression was used to calculate 5-year mortality risk while controlling for potential confounders.

resultsSurgery alone or palliative options were offered to older patients more frequently. After controlling for confounders, older patients were less likely to receive multimodality therapy for both early stage and advanced stage disease. Patients with advanced disease across all age cohorts had improved 5-year survival with surgery and adjuvant therapy.

conclusionOur analyses suggest that elderly patients have unique demographic and pathologic features. They frequently receive less treatment than similarly staged younger patients, yet they benefit from multimodality therapy when feasible. These data suggest an urgent need to critically appraise the care of elderly OCSCC patients within the broader context of their individual comorbidity burden, functional status, and treatment goals.

Indexed as

Age FactorsCarcinoma, Squamous CellClinical Decision-MakingMouth NeoplasmsAgedDatabases, FactualHumansNeoplasm StagingRetrospective StudiesAge-dependent careElderly careHead and neck cancerOral cavity cancerSquamous cell carcinomaTreatment decision making

Identifiers

PMID33991757
PMCPMC8984992
OpenAlexW3163792926

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.