Evidence map›Paper›PMID 33991698›Full record

ArticleNeuroImage2021

LayNii: A software suite for layer-fMRI.

Laurentius Renzo Huber, Benedikt A Poser, Peter A Bandettini, Kabir Arora, Konrad Wagstyl, Shinho Cho, Jozien Goense, Nils Nothnagel, Andrew Tyler Morgan, Job van den Hurk and 5 more

Open access · goldAbstract read
In one paragraph

Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 159 citations in OpenAlex.

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  4. Structural MRI across lifespan reveals differential thalamic trajectories in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

Laurentius Renzo HuberMBIC, Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands. Electronic address: renzohuber@gmail.com.
Benedikt A PoserMBIC, Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands.
Peter A BandettiniNIMH, NIH, Bethesda, MD, USA.
Kabir AroraMBIC, Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands.
Konrad WagstylWellcome Centre for Human Neuroimaging, University College London, London, UK.
Shinho ChoCMRR, University of Minneapolis, MN, USA.
Jozien GoenseUniversity of Glasgow, UK.
Nils NothnagelUniversity of Glasgow, UK.
Andrew Tyler MorganUniversity of Glasgow, UK.
Job van den HurkScannexus, Maastricht, the Netherlands.
Anna K MüllerGoethe University Frankfurt, Frankfurt, Germany.
Richard C ReynoldsNIMH, NIH, Bethesda, MD, USA.
Daniel R GlenNIMH, NIH, Bethesda, MD, USA.
Rainer GoebelMBIC, Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Brain Innovation, Maastricht, the Netherlands.
Omer Faruk GulbanMBIC, Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Brain Innovation, Maastricht, the Netherlands.
Maastricht University · NLUniversity of Glasgow · GBGoethe University Frankfurt · DEUniversity of Minnesota · USWellcome Centre for Human Neuroimaging · GB

Funding

Functional MRI Method DevelopmentZIAMH002783 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BANDETTINI, PETER · 2009 to 2025
$38.4M
Scientific and Statistical Computing CoreZICMH002888 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI TAYLOR, PAUL · 2009 to 2025
$30.9M
Foundations of MRI Corticography for mesoscale organization and neuronal circuitryR01MH111444 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI FEINBERG, DAVID ALAN · 2016 to 2020
$5.1M
Intramural NIH HHS ZIA MH002783Medical Research Council MR/N003403/1Medical Research Council MR/N008537/1Medical Research Council MR/R005745/1NIMH NIH HHS R01 MH111444Wellcome Trust 215901Wellcome Trust 215901/Z/19/Z
6 · The paper itself

Abstract

High-resolution fMRI in the sub-millimeter regime allows researchers to resolve brain activity across cortical layers and columns non-invasively. While these high-resolution data make it possible to address novel questions of directional information flow within and across brain circuits, the corresponding data analyses are challenged by MRI artifacts, including image blurring, image distortions, low SNR, and restricted coverage. These challenges often result in insufficient spatial accuracy of conventional analysis pipelines. Here we introduce a new software suite that is specifically designed for layer-specific functional MRI: LayNii. This toolbox is a collection of command-line executable programs written in C/C++ and is distributed opensource and as pre-compiled binaries for Linux, Windows, and macOS. LayNii is designed for layer-fMRI data that suffer from SNR and coverage constraints and thus cannot be straightforwardly analyzed in alternative software packages. Some of the most popular programs of LayNii contain 'layerification' and columnarization in the native voxel space of functional data as well as many other layer-fMRI specific analysis tasks: layer-specific smoothing, model-based vein mitigation of GE-BOLD data, quality assessment of artifact dominated sub-millimeter fMRI, as well as analyses of VASO data.

Indexed as

Functional NeuroimagingImage Processing, Computer-AssistedMagnetic Resonance ImagingSoftwareBrainHumans

Identifiers

PMID33991698
PMCPMC7615890
OpenAlexW3163496149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.