ArticleAmerican journal of ophthalmology2021
The Role of Temperature Change, Ambient Temperature, and Relative Humidity in Allergic Conjunctivitis in a US Veteran Population.
Article in American journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Climate Determinants of Keratoconus: Insights From a Systematic Review of Prevalence.Investigative ophthalmology & visual science · 2025Pooled it
- Influence of environmental pollutants and climatic factors on ocular allergy and dry eye.The World Allergy Organization journal · 2026Article
- Environmental Triggers and Ocular Disease Networks: Analyzing the Impact of Air Pollutants and Meteorological Factors Using Fuzzy Cognitive Maps.Environment & health (Washington, D.C.) · 2026Article
- Climate Change, Heat Stress, and Kidney Disease-Associated Mortality and Health Care Utilization.Kidney international reports · 2024Article
- Impact of temperature and relative humidity variability on children's allergic diseases and critical time window identification.BMC public health · 2024Article
- Editorial: The impact of clinical and environmental toxicological exposures and eye health.Frontiers in toxicology · 2024Article
- Association Between Particulate Matter Pollutants and Ophthalmology Visits for Ocular Surface Irritation and Allergy.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Nonlinear effects of humidex on risk of outpatient visit for allergic conjunctivitis among children and adolescents in Shanghai, China: A time series analysis.Journal of global health · 2023Article
- Relationship between temperature variability and daily hospitalisations in Hong Kong over two decades.Journal of global health · 2023Article
- [Current and future effects of climate change on ophthalmology].Die Ophthalmologie · 2022Review
- [Sustainability in ophthalmology : Adaptation to the climate crisis and mitigation].Die Ophthalmologie · 2022Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
purposeStudies have implicated temperature and humidity in the pathogenesis of allergic conjunctivitis (AC), as these conditions facilitate air particulate and aeroallergen dispersion and tear film instability. Research also suggests that variation in temperature is associated with risk of asthma, but similar data are limited for AC. This study examined associations between several meteorologic conditions, including temperature variation, and AC visit risk.
designRetrospective, case-crossover study.
methodsData on individuals diagnosed with AC (via International Classification of Diseases-Ninth Edition [ICD-9]) at a Veterans Affairs clinic from January 2010-December 2013 was extracted. Local climate data were obtained from the National Climactic Data Center. Utilizing a case-crossover design, all cases were assigned a random control date 90-250 days prior to diagnosis. Daily time-lagged exposures were computed for 30-day lags. The associations between temperature, temperature variation (standard deviation [SD] of temperature), relative humidity (RH), and temperature-RH interaction with visit risk were examined via multivariate logistic regression models both at the national level and across domestic climate regions.
resultsOverall, 74,951 subjects made 116,162 visits for AC. Prevalence was highest in spring (>10% April-May) in the Northeast (NE) and Southeast (SE) (>15%), and lowest in winter (<6.1% December-February) in the Pacific Northwest (PNW) (<5%). AC visit risk was positively associated with temperature (OR 1.028, P < .001), SD of temperature (OR 1.054, P < .01), and temperature-RH interaction (OR 1.0003, P < .01), whereas it was negatively associated with RH (OR 0.998, P < .001). Regionally, the PNW, NE, and Lower Midwest (LMW) accounted for the strongest associations.
conclusionTemperature, temperature variation, and RH associated with AC visit risk. Observed associations were strongest in northern regions, like the PNW.
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Registered trials
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