Evidence map›Paper›PMID 33991420›Full record

ArticleBiostatistics (Oxford, England)2022

Fast approximate inference for multivariate longitudinal data.

David M Hughes, Marta García-Fiñana, Matt P Wand

Abstract read
In one paragraph

Article in Biostatistics (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Multi-response phylogenetic mixed models: concepts and application.Biological reviews of the Cambridge Philosophical Society · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David M HughesDepartment of Health Data Science, Waterhouse Building, Block F, University of Liverpool, 1-5 Brownlow Street, Liverpool, L69 3GL, UK.
Marta García-FiñanaDepartment of Health Data Science, Waterhouse Building, Block F, University of Liverpool, 1-5 Brownlow Street, Liverpool, L69 3GL, UK.
Matt P WandSchool of Mathematical and Physical Sciences, University of Technology Sydney, P.O. Box 123, Broadway, NSW 2007, AUSTRALIA.

Funding

Australian Research Council Discovery Project DP140100441Medical Research Council MR/R024847/1
6 · The paper itself

Abstract

Collecting information on multiple longitudinal outcomes is increasingly common in many clinical settings. In many cases, it is desirable to model these outcomes jointly. However, in large data sets, with many outcomes, computational burden often prevents the simultaneous modeling of multiple outcomes within a single model. We develop a mean field variational Bayes algorithm, to jointly model multiple Gaussian, Poisson, or binary longitudinal markers within a multivariate generalized linear mixed model. Through simulation studies and clinical applications (in the fields of sight threatening diabetic retinopathy and primary biliary cirrhosis), we demonstrate substantial computational savings of our approximate approach when compared to a standard Markov Chain Monte Carlo, while maintaining good levels of accuracy of model parameters.

Indexed as

AlgorithmsBayes TheoremHumansMarkov ChainsMonte Carlo MethodNormal DistributionBayesian computingGeneralized linear mixed modelMarkov chain Monte CarloMean field variational BayesMultivariate mixed modelsRepeated measurements

Identifiers

PMID33991420
PMCPMC9748580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.