ArticleEuropean journal of nutrition2021
Evaluation of potential metabolomic-based biomarkers of protein, carbohydrate and fat intakes using a controlled feeding study.
Article in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 24 citations in OpenAlex.
- Energy intake is associated with dietary macronutrient densities: inversely with protein and monounsaturated fat and positively with polyunsaturated fat and carbohydrate among postmenopausal females.The American journal of clinical nutrition · 2025Trial
- Metabolomics-Based Biomarker for Dietary Fat and Associations with Chronic Disease Risk in Postmenopausal Women.The Journal of nutrition · 2023Trial
- Plasma Metabolites Associated with a Protein-Rich Dietary Pattern: Results from the OmniHeart Trial.Molecular nutrition & food research · 2022Trial
- Calibrated dietary patterns and cancer risk in the women's health initiative cohorts.American journal of epidemiology · 2026Observational
- Biomarkers for dietary fatty acid densities among postmenopausal United States females derived using a habitual-diet human feeding study.The American journal of clinical nutrition · 2026Article
- The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition.Current developments in nutrition · 2025Article
- Metabolite Predictors of Breast and Colorectal Cancer Risk in the Women's Health Initiative.Metabolites · 2024Article
- Intake Biomarkers for Nutrition and Health: Review and Discussion of Methodology Issues.Metabolites · 2024Review
- Reply to W Willett.The Journal of nutrition · 2023Article
- Metabolomics Biomarkers for Fatty Acid Intake and Biomarker-Calibrated Fatty Acid Associations with Chronic Disease Risk in Postmenopausal Women.The Journal of nutrition · 2023Article
- Anomalous Dynamics of Labile Metabolites in Cold Human Blood Detected UsingAnalytical chemistry · 2023Article
- Acute inhalation of tungsten particles results in early signs of cardiac injury.Toxicology letters · 2023Article
- Article
- Enhancing Capacity for Food and Nutrient Intake Assessment in Population Sciences Research.Annual review of public health · 2023Review
- Demographic, Health and Lifestyle Factors Associated with the Metabolome in Older Women.Metabolites · 2023Article
- A new limit for blood metabolite analysis usingJournal of magnetic resonance open · 2022Article
- Mortality Associated with Healthy Eating Index Components and an Empirical-Scores Healthy Eating Index in a Cohort of Postmenopausal Women.The Journal of nutrition · 2022Article
- Biomarker-Calibrated Red and Combined Red and Processed Meat Intakes with Chronic Disease Risk in a Cohort of Postmenopausal Women.The Journal of nutrition · 2022Article
- Biomarkers for Components of Dietary Protein and Carbohydrate with Application to Chronic Disease Risk in Postmenopausal Women.The Journal of nutrition · 2022Article
- Predictive Modeling of Alzheimer's and Parkinson's Disease Using Metabolomic and Lipidomic Profiles from Cerebrospinal Fluid.Metabolites · 2022Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
Abstract
purposeObjective biomarkers of dietary exposure are needed to establish reliable diet-disease associations. Unfortunately, robust biomarkers of macronutrient intakes are scarce. We aimed to assess the utility of serum, 24-h urine and spot urine high-dimensional metabolites for the development of biomarkers of daily intake of total energy, protein, carbohydrate and fat, and the percent of energy from these macronutrients (%E).
methodsA 2-week controlled feeding study mimicking the participants' habitual diets was conducted among 153 postmenopausal women from the Women's Health Initiative (WHI). Fasting serum metabolomic profiles were analyzed using a targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for aqueous metabolites and a direct-injection-based quantitative lipidomics platform. Urinary metabolites were analyzed using
resultsThe highest cross-validated multiple correlation coefficients (CV-R
conclusionSelected panels of serum and urine metabolites, without the inclusion of doubly labeled water and urinary nitrogen biomarkers, give a reliable and robust prediction of daily intake of energy from protein and carbohydrate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.