ArticleCurrent microbiology2021
Effects of Amino Acids and Overexpression of dapA Gene on the Production of ε-Poly-L-lysine by Streptomyces diastatochromogenes Strains.
Article in Current microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Bioconversion of agricultural waste to ε-poly-L-lysine by an engineered Streptomyces albulus strain.World journal of microbiology & biotechnology · 2026Article
- Construction of engineered Streptomyces albulus by increasing ATP and NADH supply and efficient production of ε-poly-L-lysine from sweet potato powder.World journal of microbiology & biotechnology · 2026Article
- Physiological Insights into Enhanced Epsilon-Poly-l-Lysine Production Induced by Extract Supplement from HeterogeneousMicroorganisms · 2025Article
- Enhanced ε-Poly-L-Lysine Production inBiomolecules · 2024Article
- Constitutive and high gene expression in the diaminopimelate pathway accelerates ε-poly-L-lysine production in Streptomyces albulus.The Journal of antibiotics · 2023Article
- Integrative transcriptome and proteome revealed high-yielding mechanisms of epsilon-poly-L-lysine byFrontiers in microbiology · 2023Article
- Transcriptomic and metabolomic analyses for providing insights into the influence of polylysine synthetase on the metabolism of Streptomyces albulus.Microbial cell factories · 2022Article
- Efficient production of ε-poly-L-lysine from cassava bagasse hydrolysate used as carbon source by Streptomyces albulus US3-18.Bioprocess and biosystems engineering · 2022Article
- Recent advances in microbial ε-poly-L-lysine fermentation and its diverse applications.Biotechnology for biofuels and bioproducts · 2022Review
- Biotechnological production and application of epsilon-poly-L-lysine (ε-PL): biosynthesis and its metabolic regulation.World journal of microbiology & biotechnology · 2022Review
- AdpA, a developmental regulator, promotes ε-poly-L-lysine biosynthesis in Streptomyces albulus.Microbial cell factories · 2022Article
- Epsilon-poly-L-lysine: Recent Advances in Biomanufacturing and Applications.Frontiers in bioengineering and biotechnology · 2021Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
In this study, the strain Streptomyces diastatochromogenes 6#-7, which efficiently synthesizes ε-Poly-L-lysine, was studied and the effects of 18 amino acids and overexpression of dapA gene on the fermentation efficiency of ε-PL by S. diastatochromogenes were investigated. It was shown that L-proline, L-lysine, L-isoleucine, and L-threonine could promote the production of ε-PL. Moreover, the overexpression of the dihydrodipicolinate synthase gene (dapA) helped improve the fermentation performance of S. diastatochromogenes. The maximum ε-PL yield of the overexpressing strain (S. diastatochromogenes 12#-2) increased by 17.5% compared with the original strain in 500 mL shake flask. When the fermentation was conducted in a 5-L fermenter, the fermentation duration was extended by 48 h, and ε-PL yield reached 30.54 g/L, which was a 19.8% increase compared to the original strain. The results of this study offered a promising approach to augment the production of ε-PL from Streptomyces, thus paving the way to reduce the cost of product ε-PL and enhance the fermentation efficiency of ε-PL production.
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Registered trials
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