Evidence map›Paper›PMID 33991198›Full record

ArticlePsychopharmacology2021

Co-treatment of vitamin D supplementation with enriched environment improves synaptic plasticity and spatial learning and memory in aged rats.

Mahnaz Bayat, Kristi A Kohlmeier, Masoud Haghani, Afshin Borhani Haghighi, Azadeh Khalili, Gholamreza Bayat, Etrat Hooshmandi, Mohammad Shabani

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Article in Psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Mahnaz BayatClinical Neurology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.
Kristi A KohlmeierDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100, Copenhagen, Denmark.
Masoud HaghaniHistomorphometry and Stereology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.
Afshin Borhani HaghighiClinical Neurology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.
Azadeh KhaliliEvidence-Based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Gholamreza BayatDepartment of Physiology and Pharmacology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Etrat HooshmandiClinical Neurology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad ShabaniNeuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran. shabani@kmu.ac.ir.ORCID http://orcid.org/0000-0002-2082-5849
Shiraz University of Medical Sciences · IRJahrom University of Medical Sciences · IRKerman University of Medical Sciences · IRUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RATIONALE AND

objectiveEnvironmental enrichment (EE) has been shown in old rats to improve learning and memory. Vitamin D (VitD) has also been shown to modulate age-related, cognitive dysfunction. As both EE and VitD could work to improve cognition via enhancement of neurotrophic factors, their effects might occlude one another. Therefore, a clinically relevant question is whether noted cognition-promoting effects of EE and VitD can co-occur.

methodsAged rats were housed for 6 weeks in one of three housing conditions: environmentally enriched (EE), socially enriched (SE), or standard condition (SC). Further, a 4th group was co-treated with VitD supplementation (400 IU kg

resultsTreatment with VitD and EE housing were associated with higher score on measures of learning and memory and exhibited lower anxiety scores compared to EE alone, SE or SC as assayed in the elevated plus maze, Morris water maze, passive avoidance, and open field tasks. Additionally, in the EE + VitD group, mRNA expression levels of NGF, TrkA, BDNF, Nrf2, and IGF-1 were significantly higher compared to expression seen in the EE group. Furthermore, field potential recordings showed that EE + VitD resulted in a greater enhancement of hippocampal LTP and neuronal excitability when compared to EE alone.

conclusionsThese findings demonstrate that in aged rats exposure to EE and VitD results in effects on hippocampal cognitive dysfunction and molecular mechanisms which are greater than effects of EE alone, suggesting potential for synergistic therapeutic effects for management of age-related cognitive decline.

Indexed as

EnvironmentAgingAnimalsCognitionDietary SupplementsHippocampusMaleMaze LearningMemoryNeuronal PlasticityRatsRats, Sprague-DawleySpatial LearningVitamin DVitamin DAge-related cognitive declineEnriched environmentLearning and memoryNeuronal excitabilityVitamin D

Identifiers

PMID33991198
OpenAlexW3163333906

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.