Evidence map›Paper›PMID 33991196›Full record

ReviewPediatric radiology2021

Translational research in pediatric contrast-enhanced ultrasound.

Anush Sridharan, Misun Hwang, Shelby Kutty, M Beth McCarville, Harriet J Paltiel, Maciej Piskunowicz, Sphoorti Shellikeri, Elizabeth Silvestro, George A Taylor, Ryne A Didier

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pediatric radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anush SridharanDepartment of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA. sridharana@email.chop.edu.ORCID http://orcid.org/0000-0002-9990-7117
Misun HwangDepartment of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.
Shelby KuttyTaussig Heart Center, Johns Hopkins University, Baltimore, MD, USA.
M Beth McCarvilleDepartment of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, USA.
Harriet J PaltielDepartment of Radiology, Boston Children's Hospital, Boston, MA, USA.
Maciej PiskunowiczDepartment of Radiology, Medical University of Gdansk, Gdansk, Poland.
Sphoorti ShellikeriDepartment of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.
Elizabeth SilvestroDepartment of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.
George A TaylorDepartment of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.
Ryne A DidierDepartment of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.

Funding

Novel Ultrasound Indices of Intracranial Pressure and Brain Ischemia in Neonatal HydrocephalusR01NS119473 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Misun Hwang · 2020 to 2026
$4.0M
NINDS NIH HHS R01 NS119473
6 · The paper itself

Abstract

The role of contrast-enhanced ultrasound (CEUS) imaging is being widely explored by various groups for its use in the pediatric population. Clinical implementation of new diagnostic or therapeutic techniques requires extensive and meticulous preclinical testing and evaluation. The impact of CEUS will be determined in part by the extent to which studies are oriented specifically toward a pediatric population. Rather than simply applying principles and techniques used in the adult population, these studies are expected to advance and augment preexisting knowledge with pediatric-specific information. To further develop this imaging modality for use in children, pediatric-focused preclinical research is essential. In this paper we describe the development and implementation of the pediatric-specific preclinical animal and phantom models that are being used to evaluate CEUS with the goal of clinical translation to children.

Indexed as

Contrast MediaTranslational Research, BiomedicalAnimalsChildHumansUltrasonographyContrast MediaChildrenContrast-enhanced ultrasoundFetusNeonatesPhantomTranslational researchUltrasoundUltrasound contrast agents

Identifiers

PMID33991196
PMCPMC11459366

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.