ArticleESC heart failure2021
Multimodality assessment of heart failure with preserved ejection fraction skeletal muscle reveals differences in the machinery of energy fuel metabolism.
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03479203 (Acute and Long-term Effects of E-Cigarette Aerosol Inhalation on Biomarkers of Endothelial Function and Vascular Reactivity), which is not on this map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.7field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Acute and Long-term Effects of E-Cigarette Aerosol Inhalation on Biomarkers of Endothelial Function and Vascular Reactivity
Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure With Preserved Ejection Fraction.JACC. Heart failure · 2025Trial
- Potassium Nitrate in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.JAMA cardiology · 2025Trial
- Systemic Interactions in HFpEF: A Multiorgan Perspective on Pathways and Therapeutic Targets.Journal of cardiovascular translational research · 2025Review
- Insights Into the Role of Obesity in Heart Failure With Preserved Ejection Fraction: Pathophysiology and Management.The Canadian journal of cardiology · 2025Review
- Mechanisms of exercise intolerance in heart failure with preserved ejection fraction (HFpEF).Heart failure reviews · 2025Review
- Dissecting the exercise pressor reflex in heart failure: A multi-step failure.Autonomic neuroscience : basic & clinical · 2025Review
- Impact of SGLT2i on Cardiac Remodeling and the Soleus Muscle of Infarcted Rats.Antioxidants (Basel, Switzerland) · 2025Article
- Reliability of In Vivo Creatine-Weighted Chemical Exchange Saturation Transfer (CrCEST) MRI in Calf Skeletal Muscle of Healthy Volunteers at 3 T.Journal of magnetic resonance imaging : JMRI · 2025Article
- Myocardial Proteome in Human Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2025Article
- Impact of whole-body and skeletal muscle composition on peak oxygen uptake in heart failure: a systematic review and meta-analysis.European heart journal open · 2024Article
- Identifying the Mechanisms of a Peripherally Limited Exercise Phenotype in Patients With Heart Failure With Preserved Ejection Fraction.Circulation. Heart failure · 2024Article
- Exercise intolerance in heart failure with preserved ejection fraction: Causes, consequences and the journey towards a cure.Experimental physiology · 2024Review
- Adult human cardiomyocyte mechanics in osteogenesis imperfecta.American journal of physiology. Heart and circulatory physiology · 2023Article
- Locomotor and respiratory muscle abnormalities in HFrEF and HFpEF.Frontiers in cardiovascular medicine · 2023Review
- Endotrophin, a Collagen VI Formation-Derived Peptide, in Heart Failure.NEJM evidence · 2022Article
- Empagliflozin Preserves Skeletal Muscle Function in a HFpEF Rat Model.International journal of molecular sciences · 2022Article
- Magnetic resonance imaging of cardiac metabolism in heart failure: how far have we come?European heart journal. Cardiovascular Imaging · 2022Article
- Isolated knee extensor exercise training improves skeletal muscle vasodilation, blood flow, and functional capacity in patients with HFpEF.Physiological reports · 2022Article
- In vivo assessment of OXPHOS capacity using 3 T CrCEST MRI in Friedreich's ataxia.Journal of neurology · 2022Article
- Skeletal myopathy in a rat model of postmenopausal heart failure with preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 6 institutions in 1 country.
Payman ZamaniPenn Cardiovascular Institute, Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID 0000-0002-9345-5834
Elizabeth A ProtoPenn Cardiovascular Institute, Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Neil WilsonCenter for Magnetic Resonance and Optical Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hossein FazeliniaProteomics Core, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Hua DingProteomics Core, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Lynn A SpruceProteomics Core, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Antonio DavilaPenn Acute Care Research Collaboration, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Thomas C HanffPenn Cardiovascular Institute, Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jeremy A MazurekPenn Cardiovascular Institute, Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Stuart B PrennerPenn Cardiovascular Institute, Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Benoit DesjardinsCardiovascular Imaging Section, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Kenneth B MarguliesPenn Cardiovascular Institute, Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Daniel P KellyPenn Cardiovascular Institute, Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Zoltan AranyPenn Cardiovascular Institute, Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Paschalis-Thomas DouliasChildren's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
John W ElrodCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Mitchell E AllenDepartment of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA, USA.
Shana E McCormackDivision of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Gayatri Maria SchurUniversity of Pennsylvania, Philadelphia, PA, USA.
Kevin D'AquillaCenter for Magnetic Resonance and Optical Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Dushyant KumarCenter for Magnetic Resonance and Optical Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Deepa ThakuriCenter for Magnetic Resonance and Optical Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Karthik PrabhakaranCenter for Magnetic Resonance and Optical Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michael C LanghamLaboratory for Structural, Physiologic and Functional Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
David C PooleDepartments of Kinesiology, Anatomy, and Physiology, Kansas State University, Manhattan, KS, USA.
Steven H SeeholzerProteomics Core, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Ravinder ReddyCenter for Magnetic Resonance and Optical Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Harry IschiropoulosChildren's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.
Julio A ChirinosPenn Cardiovascular Institute, Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, 19104, USA.
University of Pennsylvania · USHospital of the University of Pennsylvania · USChildren's Hospital of Philadelphia · USKansas State University · USTemple University · USVirginia Tech · US
Funding
Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4MSubclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)R01AG058969 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Timothy M. Hughes, YONGMEI LIU · 2018 to 2026
$33.4MUnderstanding the relationship between obesity and tongue fat in humans and ratsP01HL094307 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PACK, ALLAN I · 2009 to 2020
$23.7MSmall and large animal surgery, physiology and histologyP01HL134608 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Raj Kishore · 2017 to 2026
$21.0MTargeting Pathways Involved in Cardiac Injury for Novel Repair StrategiesP01HL147841 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KOCH, WALTER J. · 2020 to 2024
$11.4MTraining and DisseminationP41EB015893 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2012 to 2019
$11.3MREGULATION OF FATTY ACID OXIDATION DURING CARDIAC GROWTHR01HL058493 · NHLBI · WASHINGTON UNIVERSITY · PI KELLY, DANIEL PATRICK · 1998 to 2024
$10.6MMolecular Control of Muscle Fuel MetabolismR01DK045416 · NIDDK · WASHINGTON UNIVERSITY · PI KELLY, DANIEL PATRICK · 1996 to 2020
$8.1MProbing the Role of Mitochondrial Short-chain Carbon Homeostasis in the Hypertrophied and Failing HeartR01HL128349 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MUOIO, DEBORAH M · 2016 to 2024
$6.1MDetyrosinated microtubules in cardiomyocyte mechanicsR01HL133080 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Benjamin Lears Prosser · 2016 to 2026
$4.7MVASCULAR EFFECTS OF DIETARY SALT IN HUMANS WITH SALT-RESISTANT BPR01HL104106 · NHLBI · UNIVERSITY OF DELAWARE · PI EDWARDS, DAVID G, FARQUHAR, WILLIAM B · 2011 to 2021
$4.5MDeveloping a multi-modality, paradigm-shifting approach for in vivo assessment of the human placenta and the impact of maternal nutrition on its development and functionU01HD087180 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI LICHT, DANIEL JACQUES, SCHWARTZ, NADAV · 2015 to 2015
$4.3MNCATS NIH HHS UL1 TR001878NHLBI NIH HHS K23 HL130551NHLBI NIH HHS P01 HL094307NHLBI NIH HHS P01 HL134608NHLBI NIH HHS R01 HL104106NHLBI NIH HHS R01 HL121510NHLBI NIH HHS R01 HL122754NHLBI NIH HHS R01 HL123966NHLBI NIH HHS R01 HL133080NHLBI NIH HHS R01 HL136954NHLBI NIH HHS R01 HL139358NHLBI NIH HHS R03 HL146874NHLBI NIH HHS R56 HL136730NHLBI NIH HHS R61 HL146390NHLBI NIH HHS U10 HL110338NIA NIH HHS R01 AG058969NIBIB NIH HHS P41 EB015893NIBIB NIH HHS R21 EB022687NICHD NIH HHS U01 HD087180
Abstract
aimsSkeletal muscle (SkM) abnormalities may impact exercise capacity in patients with heart failure with preserved ejection fraction (HFpEF). We sought to quantify differences in SkM oxidative phosphorylation capacity (OxPhos), fibre composition, and the SkM proteome between HFpEF, hypertensive (HTN), and healthy participants. METHODS AND
resultsFifty-nine subjects (20 healthy, 19 HTN, and 20 HFpEF) performed a maximal-effort cardiopulmonary exercise test to define peak oxygen consumption (VO
conclusionsHeart failure with preserved ejection fraction patients demonstrate impaired functional capacity and SkM OxPhos. Reductions in the proportions of Type I myofibres, proteins required for OxPhos, and altered phosphorylation signalling in the SkM may contribute to exercise intolerance in HFpEF.
Indexed as
Heart FailureExercise ToleranceHumansMuscle, SkeletalOxygen ConsumptionProteomicsStroke VolumeExerciseHFpEFSkeletal muscle
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT03479203ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.