ArticleJournal of veterinary internal medicine2021
Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism.
Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Acquired hypocalciuric hypercalcemia in a dog.The Journal of veterinary medical science · 2025Article
- Pamidronate-induced irreversible symptomatic hypocalcemia in a dog with hypercalcemia after glucocorticoid withdrawal: a case report.BMC veterinary research · 2024Article
- Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism.Journal of veterinary internal medicine · 2021Article
- Estimates of Urinary Calcium Excretion in Dogs With and Without Calcium Oxalate Urolithiasis.Journal of veterinary internal medicineArticle
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypercortisolism affects calcium and phosphate metabolism in dogs; however, the exact mechanisms are not completely understood.
objectivesTo evaluate circulating concentrations of whole parathormone (wPTH), 25-hydroxyvitamin D (25-(OH)D), calcitriol, and fibroblast growth factor-23 (FGF-23) in dogs with naturally occurring hypercortisolism (NOHC) and healthy dogs, and their association with calcium and phosphate homeostasis. ANIMALS: Twenty-three client-owned dogs with NOHC, and 12 client or staff-owned healthy dogs.
methodsProspective cross-sectional study. The circulating concentrations of total calcium, ionized calcium (iCa), phosphate, wPTH, 25-(OH)D, calcitriol and FGF-23, and the urinary fractional excretion of phosphate (FEP) and calcium (FECa) were compared between dogs with NOHC before treatment and healthy dogs.
resultsDogs with NOHC had higher mean serum phosphate concentrations (4.81 mg/dL, SD ± 0.71 vs 3.86 mg/dL, SD ± 0.60; P < .001), median FECa (0.43%, range, 0.03-2.44 vs 0.15%, range, 0.06-0.35; P = .005), and median serum wPTH concentrations (54.6 pg/mL, range, 23.7-490 vs 24.6 pg/mL, range, 5.5-56.4; P = .003) as compared to the controls. Circulating concentrations of total calcium, iCa, and calcitriol and the FEP did not differ between groups, whereas the serum 25-(OH)D concentrations were lower in dogs with NOHC as compared to the controls (70.2 pg/mL, SD ± 42.3 vs 106.3 pg/mL, SD ± 35.3; P = .02). The dogs with NOHC had lower plasma FGF-23 concentrations than controls (316.6 pg/mL, range, 120.8-575.6 vs 448.7 pg/mL, range, 244.8-753; P = .03). CONCLUSIONS AND CLINICAL IMPORTANCE: Urine loss of calcium and hyperphosphatemia could contribute to the adrenal secondary hyperparathyroidism.
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