ArticleSchizophrenia bulletin2021
Hospital Presentation for Self-Harm in Youth as a Risk Marker for Later Psychotic and Bipolar Disorders: A Cohort Study of 59 476 Finns.
Article in Schizophrenia bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sensitivity of the clinical high-risk and familial high-risk approaches for psychotic disorders - a systematic review and meta-analysis.Psychological medicine · 2025Pooled it
- Prognostic models predicting transition to psychotic disorder using blood-based biomarkers: a systematic review and critical appraisal.Translational psychiatry · 2023Pooled it
- Suicide and Self-Harm Risk in Young People at Clinical High Risk of Psychosis: Exploring Comorbid Risk Factors and Potential Points for Intervention.Schizophrenia bulletin · 2026Article
- Using Electronic Health Records to Identify Medical Presentation for Self-harm as a Predictor of Psychotic or Bipolar Disorders: A Systems-level Alternative to the Clinical High-risk Approach.Schizophrenia bulletin · 2026Article
- Global adolescent self-harm (10-19 years): 1990-2021 trends, health inequalities, frontier analysis, and 2035 projections using global burden of disease data.Frontiers in public health · 2026Article
- Identifying suicidal ideation in Chinese higher vocational students using machine learning: a cross-sectional survey.European archives of psychiatry and clinical neuroscience · 2025Article
- Service delay in schizophrenia: case-control study of pathways to care among homeless and non-homeless patients.BJPsych open · 2025Article
- From Adolescence to Adulthood: Understanding Care Trajectories in an Early Detection and Intervention Centre in France.Early intervention in psychiatry · 2025Article
- Combinations and Temporal Associations Among Precursor Symptoms Before a First Episode of Psychosis.Schizophrenia bulletin · 2024Article
- Risk of Psychosis Among Individuals Who Have Presented to Hospital With Self-harm: A Prospective Nationwide Register Study in Sweden.Schizophrenia bulletin · 2024Article
- Proteomic Biomarkers for the Prediction of Transition to Psychosis in Individuals at Clinical High Risk: A Multi-cohort Model Development Study.Schizophrenia bulletin · 2024Article
- Medical and Psychiatric Care Preceding the First Psychotic Disorder Diagnosis.Schizophrenia bulletin · 2024Article
- An exploratory study of psychosis risk factors in individuals who are referred but do not meet criteria for an early intervention in psychosis service.BJPsych open · 2024Article
- Harmonizing early intervention strategies: scoping review of clinical high risk for psychosis and borderline personality disorder.Frontiers in psychology · 2024Article
- Suicidal Ideation and Non-Suicidal Self-Injury Following Early Childhood Psychotic Experiences in Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder-The Danish High Risk and Resilience Study, VIA 11.Schizophrenia bulletin · 2023Article
- Thoughts of self-harm in late adolescence as a risk indicator for mental disorders in early adulthood.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Predictive tools in psychosis: what is 'good enough'?Nature reviews. Neurology · 2023Article
- Mental health disorders, functioning and health-related quality of life among extensively hospitalized patients due to severe self-harm - results from the Extreme Challenges project.Frontiers in psychiatry · 2023Article
- Risk Factors for Deliberate Self-harm and Suicide Among Adolescents and Young Adults With First-Episode Psychosis.Schizophrenia bulletin · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expanding clinical strategies to identify high risk groups for psychotic and bipolar disorders is a research priority. Considering that individuals diagnosed with psychotic and bipolar disorder are at high risk of self-harm, we hypothesised the reverse order relationship would also be true (ie, self-harm would predict psychotic/bipolar disorder). Specifically, we hypothesised that hospital presentation for self-harm would be a marker of high risk for subsequent development of psychotic/bipolar disorder and sought to test this hypothesis in a large population sample. This prospective register-based study included everyone born in Finland in 1987, followed until age 28 years (N = 59 476). We identified all hospital records of self-harm presentations, as well as all ICD-10 healthcare registrations of first diagnoses of psychotic and bipolar disorders. Cox proportional hazards models were used to assess the relationship between self-harm and psychotic/bipolar disorders. Of all individuals who presented to hospital with self-harm (n = 481), 12.8% went on to receive a diagnosis of psychosis (hazard ratio [HR] = 6.03, 95% confidence interval [CI] 4.56-7.98) and 9.4% a diagnosis of bipolar disorder (HR = 7.85, 95% CI 5.73-10.76) by age 28 years. Younger age of first self-harm presentation was associated with higher risk-for individuals who presented before age 18 years, 29.1% developed a psychotic or bipolar disorder by age 28 years. Young people who present to hospital with self-harm are at high risk of future psychotic and bipolar disorders. They represent an important cohort for the prevention of serious mental illness.
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