Evidence map›Paper›PMID 33991076›Full record

ArticleCancer medicine2021

Transoral surgery for superficial head and neck cancer: National Multi-Center Survey in Japan.

Chikatoshi Katada, Manabu Muto, Satoshi Fujii, Tetsuji Yokoyama, Tomonori Yano, Akihito Watanabe, Toshiro Iizuka, Shigetaka Yoshinaga, Ichiro Tateya, Hiroki Mitani and 30 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors at 20 institutions in 1 country.

Chikatoshi KatadaDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan.ORCID 0000-0002-2713-4661
Manabu MutoDepartment of Therapeutic Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Satoshi FujiiDepartment of Molecular Pathology, Yokohama City University School of Medicine, Yokohama, Japan.
Tetsuji YokoyamaDepartment of Health Promotion, National Institute of Public Health, Wako, Japan.
Tomonori YanoDepartment of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan.
Akihito WatanabeDepartment of Otolaryngology, Keiyukai Sapporo Hospital, Sapporo, Japan.
Toshiro IizukaDepartment of Gastroenterology, Toranomon Hospital, Tokyo, Japan.
Shigetaka YoshinagaEndoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
Ichiro TateyaDepartment of Otolaryngology - Head and Neck Surgery, Kyoto University, Kyoto, Japan.
Hiroki MitaniDepartment of Head and Neck Oncology, Cancer Institute Hospital, Tokyo, Japan.
Yuichi ShimizuDivision of Endoscopy, Hokkaido University Hospital, Sapporo, Japan.
Akiko TakahashiDepartment of Endoscopy, Saku Central Hospital Advanced Care Center, Saku, Japan.
Tomoyuki KamijoDivision of Head and Neck Surgery, Shizuoka Cancer Center, Nagaizumi, Japan.
Noboru HanaokaDepartment of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.
Makoto AbeDepartment of Gastroenterology and Hepatology, Okayama University Graduate School, Okayama, Japan.
Akihiro ShiotaniDepartment of Otolaryngology-Head and Neck Surgery, National Defense Medical College, Tokorozawa, Japan.
Koichi KanoDepartment of Otorhinolaryngology - Head and Neck Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
Yukinori AsadaDepartment of Head and Neck Surgery, Miyagi Cancer Center, Natori, Japan.
Tamotsu MatsuhashiDepartment of Gastroenterology, Akita University School of Medicine, Akita, Japan.
Hirohito UmenoDepartment of Otolaryngology- Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan.
Kenji OkamiDepartment of Otolaryngology- Head and Neck Surgery, Tokai University, Isehara, Japan.
Kenichi GodaDepartment of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan.
Shinichiro HoriDepartment of Endoscopy, NHO Shikoku Cancer Center, Matsuyama, Japan.
Yoichiro OnoDepartment of Gastroenterology, Fukuoka University Chikushi Hospital, Chikushino, Japan.
Shuji TeraiDivision of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Yasuaki NagamiDepartment of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Kenichi TakemuraDepartment of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.
Kenro KawadaDepartment of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Mizuo AndoDepartment of Otolaryngology - Head and Neck Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.ORCID 0000-0002-0754-2545
Naoto ShimenoDepartment of Gastroenterology, Kobe City Medical Center General Hospital, Kobe, Japan.
Akihito AraiDepartment of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yasutoshi SakamotoKitasato Clinical Research Center, Kitasato University School of Medicine, Sagamihara, Japan.
Masaaki IchinoeDepartment of Pathology, Kitasato University School of Medicine, Sagamihara, Japan.ORCID 0000-0002-4622-0565
Tetsuo NemotoDepartment of Diagnostic Pathology, Showa University School of Medicine, Yokohama Northern Hospital, Yokohama, Japan.
Masahiro FujitaDepartment of Clinical Pathology, Sapporo Hokuyu Hospital, Sapporo, Japan.
Hidenobu WatanabeDepartment of Pathology, Pathology and Cytology Laboratories BML INC, Tokyo, Japan.
Tadakazu ShimodaDepartment of Diagnostic Pathology, Shizuoka Cancer Center, Nagaizumi, Japan.
Atsushi OchiaiExploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Takakuni KatoDepartment of Otorhinolaryngology - Head and Neck Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Ryuichi HayashiDepartment of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Kitasato University · JPNational Cancer Center Hospital East · JPJikei University School of Medicine · JPKyoto University · JPShizuoka Cancer Center · JPAkita University · JPHigashi Chikushi Junior College · JPHokkaido University Hospital · JPIshikawa Prefectural Central Hospital · JPKeiyukai Sapporo Hospital · JPKobe City Medical Center General Hospital · JPKurume University · JPKyoto Prefectural University · JPMedical & Biological Laboratories (Japan) · JPMiyagi Prefectural Hospital Organization · JPNational Defense Medical College Hospital · JPNational Institute of Public Health · JPNiigata University · JPOkayama University · JPOsaka City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck cancers, especially in hypopharynx and oropharynx, are often detected at advanced stage with poor prognosis. Narrow band imaging enables detection of superficial cancers and transoral surgery is performed with curative intent. However, pathological evaluation and real-world safety and clinical outcomes have not been clearly understood. The aim of this nationwide multicenter study was to investigate the safety and efficacy of transoral surgery for superficial head and neck cancer. We collected the patients with superficial head and neck squamous cell carcinoma who were treated by transoral surgery from 27 hospitals in Japan. Central pathology review was undertaken on all of the resected specimens. The primary objective was effectiveness of transoral surgery, and the secondary objective was safety including incidence and severity of adverse events. Among the 568 patients, a total of 662 lesions were primarily treated by 575 sessions of transoral surgery. The median tumor diameter was 12 mm (range 1-75) endoscopically. Among the lesions, 57.4% were diagnosed as squamous cell carcinoma in situ. The median procedure time was 48 minutes (range 2-357). Adverse events occurred in 12.7%. Life-threatening complications occurred in 0.5%, but there were no treatment-related deaths. During a median follow-up period of 46.1 months (range 1-113), the 3-year overall survival rate, relapse-free survival rate, cause-specific survival rate, and larynx-preservation survival rate were 88.1%, 84.4%, 99.6%, and 87.5%, respectively. Transoral surgery for superficial head and neck cancer offers effective minimally invasive treatment. Clinical trials registry number: UMIN000008276.

Indexed as

AdultAgedAged, 80 and overCarcinoma in SituDisease-Free SurvivalFemaleHead and Neck NeoplasmsHumansIncidenceJapanLarynxMaleMiddle AgedNatural Orifice Endoscopic SurgeryNeoplasms, Second PrimaryOperative Timehead and neck cancerlarynx preservationpharyngeal cancersuperficial cancertransoral surgery

Identifiers

PMID33991076
PMCPMC8209601
OpenAlexW3163307602

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.