ReviewAngewandte Chemie (International ed. in English)2021
Catalytic Generation of Carbanions through Carbonyl Umpolung.
Review in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Geminal Difunctionalizations of Aliphatic Ketones and Aldehydes Enabled by Thioacetal Activation and Deep Electroreduction.Journal of the American Chemical Society · 2026Article
- Photo-enabled and thioamide-directed α-C(spNature communications · 2026Article
- Deoxygenative Cyanofunctionalization of Aldehydes and Ketones Enabled by Electrochemical Reduction.Journal of the American Chemical Society · 2025Article
- Photochemically-Enabled Umpolung Conversion of 2-Acyloxybenzaldehydes into 2-Hydroxybenzofuranones.Molecules (Basel, Switzerland) · 2025Article
- Research Progress on the Reaction of Carbon Dioxide with Hydrazones and Their Derivatives.Molecules (Basel, Switzerland) · 2025Review
- Cathodic tandem alkylation/dearomatization of heterocycles enabled by Al-facilitated carbonyl deoxygenation.Nature communications · 2025Article
- Catalytic Aldehyde-Alkyne Couplings Triggered by Ketyl Radicals.Organic letters · 2024Article
- Visible Light-Driven Excited-State Copper-BINAP Catalysis for Accessing Diverse Chemical Reactions.Chem catalysis · 2024Article
- Electroreductive alkylations of (hetero)arenes with carboxylic acids.Nature communications · 2024Article
- Visible-light-driven alkene dicarboxylation with formate and COChemical science · 2024Article
- Synthesis of substituted benzylboronates by light promoted homologation of boronic acids withChemical science · 2023Article
- A Porphyrin Iron(III) π-Dication Species and its Relevance in Catalyst Design for the Umpolung of Nucleophiles.Angewandte Chemie (International ed. in English) · 2023Article
- Electrochemically Driven Deoxygenative Borylation of Alcohols and Carbonyl Compounds.Journal of the American Chemical Society · 2023Article
- Enantioselective total syntheses of six natural and two proposed meroterpenoids fromChemical science · 2023Article
- Photo-Induced Homologation of Carbonyl Compounds for Iterative Syntheses.Angewandte Chemie (International ed. in English) · 2022Article
- Metal-Metal BondInorganic chemistry · 2022Article
- Umpolung of an Aliphatic Ketone to a Magnesium Ketone-1,2-diide Complex with Vicinal Dianionic Charge.Angewandte Chemie (International ed. in English) · 2022Article
- Article
- Ruthenium(ii)-catalyzed regioselective 1,6-conjugate addition of umpolung aldehydes as carbanion equivalents.Chemical science · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Carbonyl Umpolung is a powerful strategy in organic chemistry to construct complex molecules. Over the last few years, versatile catalytic approaches for the generation of acyl anion equivalents from carbonyl compounds have been developed, but methods to obtain alkyl carbanions from carbonyl compounds in a catalytic fashion are still at an early stage. This Minireview summarizes recent progress in the generation of alkyl carbanions through catalytic carbonyl Umpolung. Two different catalytic approaches can be utilized to enable the generation of alkyl carbanions from carbonyl compounds: the catalytic Wolff-Kishner reaction and the catalytic single-electron reduction of carbonyl compounds and imines. We discuss the reaction scope, mechanistic insights, and synthetic applications of the methods as well as potential future developments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.