ArticleInternational journal of cancer2021
Umbilical metastases: Real-world data shows abysmal outcome.
Article in International journal of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Umbilical granuloma mimicking Sister Mary Joseph's nodule.International journal of women's dermatology · 2026Article
- Article
- Sister Mary Joseph's Nodule Revealing Klatskin's Cholangiocarcinoma at the Yalgado Ouedraogo University Hospital: Case Report and Literature Review.Clinical case reports · 2025Article
- A Sister Mary Joseph's nodule in fallopian tube cancer: exploring the metastatic pathway through gene expression profiling-a case report.Journal of medical case reports · 2025Article
- Sister Mary Joseph's nodule as the first presenting sign of advanced fallopian tube carcinoma: A case report.The Journal of international medical research · 2025Article
- A dark umbilical nodule in a postmenopausal woman: What is your diagnosis?Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2025Article
- Radiation Therapy for Sister Mary Joseph's Nodule: A Review.Advances in radiation oncology · 2024Review
- Long-term survival of the Sister Mary Joseph nodule originating from breast cancer: A case report.World journal of clinical cases · 2023Article
- Cholangiocarcinoma Resembling IgG4-related Sclerosing Cholangitis.Internal medicine (Tokyo, Japan) · 2023Article
- Dedifferentiated umbilical metastases from low grade endometrioid endometrial adenocarcinoma complicated by super-obesity: A case report.International journal of surgery case reports · 2023Article
- Indurated erythema of abdominal skin: An unusual presentation of metastatic endometrial carcinoma-Case report with literature review.Skin health and disease · 2023Article
- Sex-based differences in nuclear medicine imaging and therapy.European journal of nuclear medicine and molecular imaging · 2023Article
- Article
- Umbilical Endometriosis: A Systematic Literature Review and Pathogenic Theory Proposal.Journal of clinical medicine · 2022Review
- Umbilical metastases: Real-world data shows abysmal outcome.International journal of cancer · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Umbilical metastases form a clinical challenge, especially when they represent the first sign of malignant disease and the primary tumor is unknown. Our study aims to generate insight into the origin and timing of umbilical metastasis, as well as patient survival, using population-based data. A nationwide review of pathology records of patients diagnosed with an umbilical metastasis between 1979 and 2015 was performed. Data was collected from the Nationwide Network and Registry of Histopathology and Cytopathology (PALGA) and the Netherlands Cancer Registry. Kaplan-Meier analyses and log-rank testing were used to estimate overall survival and a Cox proportional hazard model was used to determine multivariable hazard ratios. A total of 806 patients with an umbilical metastasis were included. There were 210 male (26.1%) and 596 female (73.9%) patients. Distribution of umbilical metastases was different between male and female patients due to the high incidence of umbilical metastases originating from the ovaries in females. They most frequently originated from the ovaries in female patients (38.8%) and from the colon in male patients (43.8%). In 18% of cases no primary tumor could be identified. Prognosis after diagnosis of an umbilical metastasis was dismal with a median survival of 7.9 months (95% confidence interval 6.7-9.1). The origin of the primary tumor was an independent prognostic factor for overall survival. In conclusion, umbilical metastases relatively rare, mainly originating from intraabdominal primary tumors. Survival is dependent on the origin of the primary tumor and poor overall survival rates warrant early recognition.
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