Evidence map›Paper›PMID 33990651›Full record

Trial reportScientific reports2021

First Asian population study of stereotactic body radiation therapy for ventricular arrhythmias.

Li-Ting Ho, Jenny Ling-Yu Chen, Hsing-Min Chan, Yu-Cheng Huang, Mao-Yuan Su, Sung-Hsin Kuo, Yeun-Chung Chang, Jiunn-Lee Lin, Wen-Jone Chen, Wen-Jeng Lee and 1 more

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Stereotactic cardiac radiotherapy for refractory ventricular tachycardia in structural heart disease patients: a systematic review.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Pooled it
  3. Review
  4. Article
  5. Stereotactic radioablation for ventricular tachycardia in patients untreatable by catheter ablation: evidence of efficacy, safety, and impact on coronary arteries.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  6. Application of stereotactic radiotherapy in the treatment of cardiovascular diseases through sympathectomy.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  7. Review
  8. Patient selection, ventricular tachycardia substrate delineation, and data transfer for stereotactic arrhythmia radioablation: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology and the Heart Rhythm Society.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  9. Radiation therapy for ventricular arrhythmias.Journal of medical imaging and radiation oncology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Li-Ting HoDivision of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, No. 7, Chuang-Shan South Road, Taipei, 100, Taiwan.
Jenny Ling-Yu ChenDivision of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, No. 7, Chuang-Shan South Road, Taipei, 100, Taiwan.
Hsing-Min ChanDivision of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, No. 7, Chuang-Shan South Road, Taipei, 100, Taiwan.
Yu-Cheng HuangDepartment of Radiology, National Taiwan University College of Medicine, No. 7, Chuang-Shan South Road, Taipei, 100, Taiwan.
Mao-Yuan SuDepartment of Medical Imaging, National Taiwan University College of Medicine and Hospital, No. 7, Chuang-Shan South Road, Taipei, 100, Taiwan.
Sung-Hsin KuoDivision of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, No. 7, Chuang-Shan South Road, Taipei, 100, Taiwan.
Yeun-Chung ChangDepartment of Radiology, National Taiwan University College of Medicine, No. 7, Chuang-Shan South Road, Taipei, 100, Taiwan.
Jiunn-Lee LinCardiovascular Center, Taipei Medical University Shuang Ho Hospital, No. 7, Chuang-Shan South Road, Taipei, 100, Taiwan.
Wen-Jone ChenDivision of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, No. 7, Chuang-Shan South Road, Taipei, 100, Taiwan.
Wen-Jeng LeeDepartment of Radiology, National Taiwan University College of Medicine, No. 7, Chuang-Shan South Road, Taipei, 100, Taiwan. wenjeng@gmail.com.
Lian-Yu LinDivision of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, No. 7, Chuang-Shan South Road, Taipei, 100, Taiwan. hspenos@gmail.com.
National Taiwan University Hospital · TWNational Taiwan University · TWTaipei Medical University-Shuang Ho Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the first Asian series on stereotactic body radiation (SBRT) for refractory ventricular arrhythmia (VA) in Taiwanese patients. Three-dimensional electroanatomic maps, delayed-enhancement magnetic resonance imaging (DE-MRI), and dual-energy computed tomography (CT) were used to identify scar substrates. The main target volume was treated with a single radiation dose of 25 Gy and the margin volume received 20 Gy using simultaneous integrated boost delivered by the Varian TrueBeam system. Efficacy was assessed according to VA events recorded by an implantable cardioverter-defibrillator (ICD) or a 24-h Holter recorder. Pre- and post-radiation therapy imaging studies were performed. From February 2019 to December 2019, seven patients (six men, one woman; mean age, 55 years) were enrolled and treated. One patient died of hepatic failure. In the remaining six patients, at a median follow-up of 14.5 months, the VA burden and ICD shocks significantly decreased (only one patient with one ICD shock after treatment). Increased intensity on DE-MRI might be associated with a lower risk for VA recurrence, whereas dual-energy CT had lower detection sensitivity. No acute or minimal late adverse events occurred. In patients with refractory VA, SBRT is associated with a marked reduction in VA burden and ICD shocks, and DE-MRI might be useful for monitoring treatment effects.

Indexed as

Arrhythmias, CardiacCicatrixDefibrillators, ImplantableFemaleFollow-Up StudiesHeartHumansMagnetic Resonance ImagingMaleMiddle AgedMyocardiumRadiosurgeryTaiwanTomography, X-Ray ComputedTreatment Outcome

Identifiers

PMID33990651
PMCPMC8121933
OpenAlexW3160997534

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.