ArticleNPJ Parkinson's disease2021
The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson's disease using inertial sensor.
Article in NPJ Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 29 citations in OpenAlex.
- Impacts of Cognitive Load and Task Initiation Timing on Gait Performance in Parkinson's Disease: A Dual-Task Paradigm Study.CNS neuroscience & therapeutics · 2026Article
- Quantitative Analysis of Timed Up and Go Metrics Across Parkinson's Disease Severity and Their Clinical Correlations.Diagnostics (Basel, Switzerland) · 2026Article
- Effects of Dual Tasking on Intersegmental Coordination During Walking in People with Parkinson's Disease: A Cross-Sectional Case-Control Study.Geriatrics (Basel, Switzerland) · 2026Article
- EEG Sensor-Based Parkinson's Disease Detection Using a Multi-Domain Feature Fusion Network.Sensors (Basel, Switzerland) · 2025Article
- Retrospective Frailty Assessment in Older Adults Using Inertial Measurement Unit-Based Deep Learning on Gait Spectrograms.Sensors (Basel, Switzerland) · 2025Article
- Analysis of gait characteristics to evaluate injury risk after high-intensity exercise, focusing on canoe athletes: a preliminary study.Frontiers in sports and active living · 2025Article
- A New Measure for Quantifying Four-Limb Coordination of Human Gait Based on Mobility Sensors.Sensors (Basel, Switzerland) · 2024Article
- Kinematic network of joint motion provides insight on gait coordination: An observational study on Parkinson's disease.Heliyon · 2024Article
- Freezing of gait assessment with inertial measurement units and deep learning: effect of tasks, medication states, and stops.Journal of neuroengineering and rehabilitation · 2024Article
- Minimal clinically important differences of spatiotemporal gait variables in Parkinson disease.Gait & posture · 2024Article
- The effect of dopaminergic treatment on whole body kinematics explored through network theory.Scientific reports · 2024Article
- Clinical and device-based predictors of improved experience of activities of daily living after a multidisciplinary inpatient treatment for people with Parkinson's disease: a cohort study.Therapeutic advances in neurological disorders · 2024Article
- Assessing falls in the elderly population using G-STRIDE foot-mounted inertial sensor.Scientific reports · 2023Article
- Gait characteristics related to fall risk in patients with cerebral small vessel disease.Frontiers in neurology · 2023Article
- Parkinson's Disease Wearable Gait Analysis: Kinematic and Dynamic Markers for Diagnosis.Sensors (Basel, Switzerland) · 2022Article
- Parkinson's disease multimodal complex treatment improves gait performance: an exploratory wearable digital device-supported study.Journal of neurology · 2022Observational
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate the effect of levodopa on the phase coordination index (PCI) and gait asymmetry (GA) of patients with Parkinson's disease (PD) and to investigate correlations between the severity of motor symptoms and gait parameters measured using an inertial sensor. Twenty-six patients with mild-to-moderate-stage PD who were taking levodopa participated in this study. The Unified Parkinson's Disease Rating Scale part III (UPDRS III) was used to assess the severity of motor impairment. The Postural Instability and Gait Difficulty (PIGD) subscore was calculated from UPDRS III. Patients were assessed while walking a 20-m corridor in both "OFF" and "ON" levodopa medication states, and gait analysis was performed using inertial sensors. We investigated the changes in gait parameters after taking levodopa and the correlations between UPDRS III, PIGD, and gait parameters. There was a significant improvement in PCI after taking levodopa. No significant effect of levodopa on GA was found. In "OFF" state, PCI and GA were not correlated with UPDRS III and PIGD. However, in "ON" state, PCI was the only gait parameter correlating with UPDRS III, and it was also highly correlated with PIGD compared to other gait parameters. Significant improvement in bilateral-phase coordination was identified in patients with PD after taking levodopa, without significant change in gait symmetricity. Considering the high correlation with UDPRS III and PIGD in "ON" states, PCI may be a useful and quantitative parameter to measure the severity of motor symptoms in PD patients who are on medication.
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Registered trials
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