ArticleNature communications2021
The membrane-localized protein kinase MAP4K4/TOT3 regulates thermomorphogenesis.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 67 citations in OpenAlex.
- Principles and mechanisms of plant acclimation to heat stress.Nature reviews. Molecular cell biology · 2026Review
- Evolutionary tuning of the molecular charge state of UBP24 shapes responses to high temperature.Nature plants · 2026Article
- Shaping Plant Adaptation in a Warmer World: Developmental Plasticity Under Moderately Elevated Temperatures.Plants (Basel, Switzerland) · 2026Review
- Temperature regulation in plants: From molecular mechanisms to climate-resilient crop improvement.Journal of integrative plant biology · 2026Review
- Plant cell wall remodeling and peptide signaling under abiotic and biotic stress.Plant communications · 2026Review
- Genome wide characterization and expression profiling of protein disulfide isomerase (PDI) gene family members in watermelon under cold stress.Genes & genomics · 2026Article
- MAP4K1 and MAP4K2 regulate ABA-induced and CaScience advances · 2025Article
- Research Progress on Responses and Regulatory Mechanisms of Plants Under High Temperature.Current issues in molecular biology · 2025Review
- Warm temperature suppresses plant systemic acquired resistance by intercepting N-hydroxypipecolic acid biosynthesis.The Plant journal : for cell and molecular biology · 2025Article
- Integrative Identification of Chloroplast Metabolism-Related RETICULATA-RELATED Genes in Soybean.Plants (Basel, Switzerland) · 2025Article
- Mechanisms of plant acclimation to multiple abiotic stresses.Communications biology · 2025Review
- UV-B increases active phytochrome B to suppress thermomorphogenesis and enhance UV-B stress tolerance at high temperatures.Plant communications · 2025Article
- Stomatal opening under high temperatures is controlled by the OST1-regulated TOT3-AHA1 module.Nature plants · 2025Article
- TOT3-AHA1 module: its role in fine-tuning stomatal responses.Frontiers in plant science · 2025Review
- SlCPK27 cross-links SlHY5 and SlPIF4 in brassinosteroid-dependent photo- and thermo-morphogenesis in tomato.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- CCaP1/CCaP2/CCaP3 interact with plasma membrane HPlant communications · 2024Article
- Genome-wide characterization and expression profiling of E2F/DP gene family members in response to abiotic stress in tomato (Solanum lycopersicum L.).BMC plant biology · 2024Article
- The cAMP-dependent phosphorylation footprint in response to heat stress.Plant cell reports · 2024Article
- High-throughput field phenotyping reveals that selection in breeding has affected the phenology and temperature response of wheat in the stem elongation phase.Journal of experimental botany · 2024Article
- Bioinformatic Identification and Expression Analyses of the MAPK-MAP4K Gene Family Reveal a Putative Functional MAP4K10-MAP3K7/8-MAP2K1/11-MAPK3/6 Cascade in Wheat (Plants (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants respond to mild warm temperature conditions by increased elongation growth of organs to enhance cooling capacity, in a process called thermomorphogenesis. To this date, the regulation of thermomorphogenesis has been exclusively shown to intersect with light signalling pathways. To identify regulators of thermomorphogenesis that are conserved in flowering plants, we map changes in protein phosphorylation in both dicots and monocots exposed to warm temperature. We identify MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE4 (MAP4K4)/TARGET OF TEMPERATURE3 (TOT3) as a regulator of thermomorphogenesis that impinges on brassinosteroid signalling in Arabidopsis thaliana. In addition, we show that TOT3 plays a role in thermal response in wheat, a monocot crop. Altogether, the conserved thermal regulation by TOT3 expands our knowledge of thermomorphogenesis beyond the well-studied pathways and can contribute to ensuring food security under a changing climate.
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