Evidence map›Paper›PMID 33990594›Full record

ArticleNature communications2021

Oxygen suppression of macroscopic multicellularity.

G Ozan Bozdag, Eric Libby, Rozenn Pineau, Christopher T Reinhard, William C Ratcliff

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Multicellularity for free.Nature ecology & evolution · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Open problems in synthetic multicellularity.NPJ systems biology and applications · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

G Ozan BozdagSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA. ozan.bozdag@gmail.com.ORCID http://orcid.org/0000-0002-0931-2399
Eric LibbyIntegrated Science Lab, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-6569-5793
Rozenn PineauSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Christopher T ReinhardSchool of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-2632-1027
William C RatcliffSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA. william.ratcliff@biology.gatech.edu.ORCID http://orcid.org/0000-0002-6837-8355

Funding

Using directed evolution to study the origins of multicellular development.R35GM138030 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI William Croft Ratcliff · 2020 to 2026
$2.8M
NIGMS NIH HHS R35 GM138030
6 · The paper itself

Abstract

Atmospheric oxygen is thought to have played a vital role in the evolution of large, complex multicellular organisms. Challenging the prevailing theory, we show that the transition from an anaerobic to an aerobic world can strongly suppress the evolution of macroscopic multicellularity. Here we select for increased size in multicellular 'snowflake' yeast across a range of metabolically-available O

Indexed as

Biological EvolutionModels, BiologicalAerobiosisAnaerobiosisBiophysical PhenomenaDirected Molecular EvolutionDNA-Binding ProteinsEukaryotic CellsGene DeletionGenetic EngineeringOxygenSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSelection, GeneticSynthetic BiologyTranscription FactorsACE2 protein, S cerevisiaeDNA-Binding ProteinsOxygenSaccharomyces cerevisiae ProteinsTranscription Factors

Identifiers

PMID33990594
PMCPMC8121917

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.