Evidence map›Paper›PMID 33990318›Full record

ArticleScience advances2021

An inverse-breathing encapsulation system for cell delivery.

Long-Hai Wang, Alexander Ulrich Ernst, James Arthur Flanders, Wanjun Liu, Xi Wang, Ashim K Datta, Boris Epel, Mrignayani Kotecha, Klearchos K Papas, Minglin Ma

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 72 citations in OpenAlex.

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  8. Reconfigurable animal bed-EPR resonator assembly for multimodal co-registration.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2026
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  10. Computationally efficient 4D spectral-spatial EPR imaging.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2025
    Article
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  12. Accelerated EPR imaging using deep learning denoising.Magnetic resonance in medicine · 2025
    Article
  13. Article
  14. Oxygen dynamics and delivery strategies to enhance beta cell replacement therapy.American journal of physiology. Cell physiology · 2025
    Review
  15. Review
  16. Islet Cell Replacement and Regeneration for Type 1 Diabetes: Current Developments and Future Prospects.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Long-Hai WangBiological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-6529-7031
Alexander Ulrich ErnstBiological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA.
James Arthur FlandersDepartment of Clinical Sciences, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-9878-5736
Wanjun LiuBiological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-6472-6247
Xi WangBiological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0003-3415-7092
Ashim K DattaBiological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-1397-6892
Boris EpelDepartment of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-1382-7029
Mrignayani KotechaO2M Technologies LLC, Chicago, IL 60612, USA.
Klearchos K PapasDepartment of Surgery, University of Arizona, Tucson, AZ 85724, USA.ORCID 0000-0002-4554-0911
Minglin MaBiological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA. mm826@cornell.edu.
Cornell University · USCM Technologies (United States) · USUniversity of Arizona · USUniversity of Chicago · US

Funding

Preclinical Oxygen Imager to Model Efficient Cancer TreatmentR44CA224840 · NCI · O2M TECHNOLOGIES, LLC · PI KOTECHA, MRIGNAYANI · 2019 to 2020
$2.3M
Engineering an Islet Thread from zwitterionically modified alginates for type 1 diabetesR01DK105967 · NIDDK · CORNELL UNIVERSITY · PI MA, MINGLIN · 2018 to 2022
$1.9M
Robust Small Animal Oxygen Imager to Model Enhanced Cancer TreatmentR43CA224840 · NCI · O2M TECHNOLOGIES, LLC · PI EPEL, BORIS, KOTECHA, MRIGNAYANI · 2018 to 2018
$358k
NCI NIH HHS R43 CA224840NCI NIH HHS R44 CA224840NIDDK NIH HHS R01 DK105967
6 · The paper itself

Abstract

Cell encapsulation represents a promising therapeutic strategy for many hormone-deficient diseases such as type 1 diabetes (T1D). However, adequate oxygenation of the encapsulated cells remains a challenge, especially in the poorly oxygenated subcutaneous site. Here, we present an encapsulation system that generates oxygen (O

Identifiers

PMID33990318
PMCPMC8121434
OpenAlexW3163890065

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.