ArticleReproductive biology and endocrinology : RB&E2021
Proteinuria may be an indicator of adverse pregnancy outcomes in patients with preeclampsia: a retrospective study.
Article in Reproductive biology and endocrinology : RB&E, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Diagnostic performance of urinary adipsin as a screening biomarker for pre-eclampsia.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Article
- Epidemiological Risk Factor Analysis for Maternal Mortality Associated with Eclampsia: A Single-Center Study from Tertiary Hospital Garut.International journal of women's health · 2026Article
- Clinical significance of severe proteinuria in preeclampsia: a multicenter study of maternal and neonatal outcomes.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Evaluation of oxidative stress markers and the angiogenic factors in preeclampsia and associated features.BMC pregnancy and childbirth · 2025Article
- Article
- Could Low Serum Albumin Level Be an Independent Marker of Severe Preeclampsia?Healthcare (Basel, Switzerland) · 2025Article
- An explainable machine learning model for predicting preterm birth in pregnant women with gestational diabetes mellitus and hypertensive disorders of pregnancy: development and external validation.Frontiers in endocrinology · 2025Article
- Preeclampsia: Etiology, Pathophysiology, Risk Factors, Impact and Prevention: A Narrative Review.Iranian journal of public health · 2024Review
- Evaluation of the Human Placental Microbiota in Early- and Late-Onset Pre-Eclampsia.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Article
- Intact NOX2 in T Cells Mediates Pregnancy-Induced Renal Damage in Dahl SS Rats.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Prediction of adverse maternal and perinatal outcomes associated with pre-eclampsia and hypertensive disorders of pregnancy: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- Article
- Urinary protein and coagulation-fibrinolysis indicators in preeclampsia: Expression and significance.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Effects of magnesium sulfate combined with labetalol on vascular endothelial function and pregnancy outcomes in pregnant women with preeclampsia.American journal of translational research · 2024Article
- Predictive value of placental growth factor level for adverse pregnancy outcome in twin pregnancies at advanced maternal age.American journal of translational research · 2024Article
- Value of proteinuria in evaluating the severity of HELLP and its maternal and neonatal outcomes.BMC pregnancy and childbirth · 2023Article
- Article
- Development and evaluation of a nomogram for adverse outcomes of preeclampsia in Chinese pregnant women.BMC pregnancy and childbirth · 2022Article
- Urinary Protein-to-Creatinine Ratio: An Indicator of Adverse Clinical Outcomes in Preeclampsia With Proteinuria.Cureus · 2022Article
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Abstract
backgroundProteinuria is one of the common manifestations of patients with preeclampsia (PE), but whether the severity of proteinuria is related to the pregnancy outcome of patients with preeclampsia remains controversial. The present study aimed to determine the relationship between 24-h proteinuria and adverse outcomes in patients with preeclampsia.
methodsThe present retrospective study included 329 pregnant women in Chongqing, China. Patients were divided into PE group and non-PE group. PE group was stratified into three subgroups based on the level of 24-h proteinuria. Correlation analysis was used to analyze the correlation between biochemical indexes and adverse pregnancy outcome, and Logistic regression analysis was used to analyze the risk factors of adverse pregnancy outcome. The receiver operating characteristic curve (ROC) was used to evaluate the ability of 24-h urinary protein to distinguish the adverse pregnancy outcome in patients with preeclampsia.
results(1) Between PE and non-PE group, cesarean section rate in PE group was significantly higher than that in non-PE group (84.4% vs. 25.9%, p < 0.001). Laboratory findings such as uric acid and creatinine level in PE group were higher than those in non-PE group. (2) Among mild (proteinuria < 0.3 g/24 h), moderate (0.3 g/24 h ≦ proteinuria < 2 g/24 h) and massive (proteinuria ≧ 2 g/24 h) groups, the frequencies of induced labor (p = 0.006) and stillbirth (p = 0.002) increased with the increase of 24-h proteinuria. (3) Adverse outcomes were positively correlated with 24-h proteinuria (adverse maternal outcomes: r = 0.239, p = 0.002; adverse fetal outcomes: r = 0.336, p < 0.001). (4) The best 24-h proteinuria cutoff values to determine stillbirth, premature and fetal distress were 3965.0 mg/24 h, 984.75 mg/24 h and 1503.85 mg/24 h and their odds ratio (95% confidence interval) were 12.46 (3.46-44.88), 2.48 (1.15-5.37) and 10.02 (2.14-46.80), respectively.
conclusionsThe severity of 24-h proteinuia may forecast adverse outcomes in women with preeclampsia. We suggest proteinuria should be retained as one of the monitoring indexes in patients with preeclampsia.
trial registrationRetrospectively registered. (LTMCMTS202001).
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