Evidence map›Paper›PMID 33990206›Full record

ArticleReproductive biology and endocrinology : RB&E2021

Upregulated Talin1 synergistically boosts β-estradiol-induced proliferation and pro-angiogenesis of eutopic and ectopic endometrial stromal cells in adenomyosis.

Yi-Yi Wang, Hua Duan, Sha Wang, Yong-Jun Quan, Jun-Hua Huang, Zheng-Chen Guo

Open access · goldAbstract read
In one paragraph

Article in Reproductive biology and endocrinology : RB&E, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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  12. Uterine Adenomyosis: From Disease Pathogenesis to a New Medical Approach Using GnRH Antagonists.International journal of environmental research and public health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yi-Yi WangDepartment of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, No.17 Qi Helou Road, Dong Cheng District, Beijing, 100006, China.
Hua DuanDepartment of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, No.17 Qi Helou Road, Dong Cheng District, Beijing, 100006, China. duanhua@ccmu.edu.cn.ORCID https://orcid.org/0000-0002-9428-7561
Sha WangDepartment of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, No.17 Qi Helou Road, Dong Cheng District, Beijing, 100006, China.
Yong-Jun QuanDepartment of Urology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Jun-Hua HuangDepartment of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, No.17 Qi Helou Road, Dong Cheng District, Beijing, 100006, China.
Zheng-Chen GuoDepartment of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, No.17 Qi Helou Road, Dong Cheng District, Beijing, 100006, China.
Capital Medical University · CNBeijing Tongren Hospital · CN

Funding

National Key Research and Development Program of China 2018YFC1004803National Natural Science Foundation of China No. 81571412
6 · The paper itself

Abstract

Adenomyosis (ADS) is an estrogen-dependent gynecological disease with unspecified etiopathogenesis. Local hyperestrogenism may serve a key role in contributing to the origin of ADS. Talin1 is mostly identified to be overexpressed and involved in the progression of numerous human carcinomas through mediating cell proliferation, adhesion and motility. Whether Talin1 exerts an oncogenic role in the pathogenesis of ADS and puts an extra impact on the efficacy of estrogen, no relevant data are available yet. Here we demonstrated that the adenomyotic eutopic and ectopic endometrial stromal cells (ADS_Eu_ESC and ADS_Ec_ESC) treated with β-estradiol (β-E

Indexed as

AdenocarcinomaAdenomyosisAnimalsCell DivisionCell Line, TumorCells, CulturedColony-Forming Units AssayEndometrial NeoplasmsEndometriumEstradiolFemaleGene Expression RegulationHumansHuman Umbilical Vein Endothelial CellsMiceMice, Inbred BALB CEstradiolRecombinant ProteinsRNA, Small InterferingTalinTLN1 protein, humanAdenomyosis (ADS)Adenomyotic eutopic and ectopic endometrial stromal cell (ADS_Eu_ESC and ADS_Ec_ESC)Pro-angiogenesisProliferationTalin1β-Estradiol (β-E2)

Identifiers

PMID33990206
PMCPMC8120781
OpenAlexW3126154399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.