ArticleBMC musculoskeletal disorders2021
Osteitis Fibrosa Cystica and pathological fractures-the classic but neglected skeletal manifestation of primary hyperparathyroidism: a case report.
Article in BMC musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 20 citations in OpenAlex.
- Brown's Tumor Presenting as a Pathological Humerus Fracture: A Rare Diagnostic Pitfall.Journal of orthopaedic case reports · 2026Article
- Brown tumours of a rib initially detected by ultrasound: a case report.BJR case reports · 2026Article
- Osteitis fibrosa cystica recovery following parathyroidectomy for primary hyperparathyroidism: a case series and review of literature.JBMR plus · 2025Review
- Multiple fractures in primary hyperparathyroidism: a challenging case report.Oxford medical case reports · 2025Article
- Brown tumor in the pterygopalatine fossa with maxillary and sphenoidal involvement: a rare case report and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Review
- Atypical Parathyroid Tumor Causing Primary Hyperparathyroidism With a Clinical Presentation of a Brown Tumor.JCEM case reports · 2025Article
- Bone in Parathyroid Diseases Revisited: Evidence From Epidemiological, Surgical and New Drug Outcomes.Endocrine reviews · 2025Review
- Multiple brown tumor in late adolescence mimicking bone metastasis: A challenging case report.Radiology case reports · 2024Article
- Primary hyperparathyroidism due to a giant parathyroid adenoma presenting with pathological fractures and multiple brown tumors.Endocrinology, diabetes & metabolism case reports · 2024Article
- A Case of Parathyroid Adenoma with Bilateral Subtrochanteric Pathological Femur Fracture - A Rare Case Report.Journal of orthopaedic case reports · 2024Article
- Brown tumors: Retrospective analysis of 26 cases.Archives of orthopaedic and trauma surgery · 2024Article
- Brown Tumors: The Hidden Face of Primary and Renal Hyperparathyroidism Amid Real-Life Settings.Journal of clinical medicine · 2024Article
- Update on brown tumor of hyperparathyroidism.Revista da Associacao Medica Brasileira (1992) · 2024Article
- A Case of Osteitis Fibrosa Cystica of the Mandible: A Rare Presentation during Pregnancy due toJournal of the ASEAN Federation of Endocrine Societies · 2024Article
- Widespread presentation of brown tumors mimicking multiple myeloma.European journal of hybrid imaging · 2023Article
- Femoral Neck Fracture in a Pediatric Patient with Primary Hyperparathyroidism.Case reports in orthopedics · 2023Article
- Multiple Bone Cysts Caused by Hyperparathyroidism: A Case Report and Review of the Literature.Cancer diagnosis & prognosisArticle
- Primary hyperparathyroidism associated with genu valgum in a young girl: Report of a rare case.Medicine internationalArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteitis fibrosa cystica is the classic manifestation of primary hyperparathyroidism (PHPT), occurs after prolonged exposure of bone to high serum parathyroid hormone (PTH) level. It has become increasingly rare due to early detection of PHPT. CASE PRESENTATION: A 37-year-old woman was referred to our institution for fixation of multiple fractures of upper and lower extremities that had been reoccurring in the past 5 years. Her medical history showed right-shoulder, left-elbow, and right-femur fractures after a fall 5 years previously. One month ago, she sustained fractures of the right distal humerus, left tibia, and left femur without history of trauma. Upon arrival to our hospital, a thorough review of her plain radiographs demonstrated brown tumors at multiple sites, along with a salt-and-pepper appearance of the skull and a rugger-jersey spine, compatible with osteitis fibrosa cystica. Patient was diagnosed with PHPT, confirmed by high-corrected serum calcium (13.6 [8.6-10.0] mg/dl), low serum phosphate (2.2 [2.5-4.5] mg/dL), high serum alkaline phosphatase (1482 [35-105] U/L), and significantly elevated parathyroid hormone (PTH 3850 [15-65] pg/mL). A histologically confirmed, 2.5-cm parathyroid adenoma was removed by parathyroidectomy. Ten days later, closed reduction and internal fixation of the left proximal femoral shaft was performed. Pain and ambulation were significantly improved 6 months postoperatively. At the 1.5-year follow-up, fracture unions and complete mineralization of brown tumors were noted; the patient could ambulate with neither pain nor an assistive device.
conclusionsPHPT has become more asymptomatic in countries where routine calcium screening is performed. Nevertheless, the classic skeletal involvement, osteitis fibrosa cystica, should not be overlooked, particularly in young patients who present with a low-energy fracture.
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