ArticleBMC pediatrics2021
The association between ambient air pollution and birth defects in five major ethnic groups in Liuzhou, China.
Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Mapping susceptibility to air pollution and its association with birth defects: a tool for public health intervention.European journal of public health · 2025Article
- Evaluation and dynamic evolution of maternal and child health services in township health centers in ethnic minority areas of Guangxi, China.Primary health care research & development · 2025Article
- Evidence of the correlation between air pollution and different types of birth defects: based on a distribution-lag non-linear model.Frontiers in public health · 2025Article
- Current perspectives in hypospadias research: A scoping review of articles published in 2021 (Review).Experimental and therapeutic medicine · 2023Article
- Maternal exposure to ambient air pollution and risk of congenital heart defects in Suzhou, China.Frontiers in public health · 2022Article
- Birth defects data from hospital-based birth defect surveillance in Guilin, China, 2018-2020.Frontiers in public health · 2022Article
- First trimester exposure to ambient gaseous air pollutants and risk of orofacial clefts: a case-control study in Changsha, China.BMC oral health · 2021Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies suggest that exposure to ambient air pollution during pregnancy may be associated with increased risks of birth defects (BDs), but conclusions have been inconsistent. This study describes the ethnic distribution of major BDs and examines the relationship between air pollution and BDs among different ethnic groups in Liuzhou city, China.
methodsSurveillance data of infants born in 114 registered hospitals in Liuzhou in 2019 were analyzed to determine the epidemiology of BDs across five major ethnic groups. Concentrations of six air pollutants (PM2.5, PM10, SO2, CO, NO2, O3) were obtained from the Liuzhou Environmental Protection Bureau. Logistic regression was used to examine the associations between ambient air pollution exposure and risk of BDs.
resultsAmong 32,549 infants, 635 infants had BDs, yielding a prevalence of 19.5 per 1000 perinatal infants. Dong ethnic group had the highest prevalence of BDs (2.59%), followed by Yao (2.57%), Miao (2.35%), Zhuang (2.07%), and Han (1.75%). Relative to the Han ethnic group, infants from Zhuang, Miao, Yao and Dong groups had lower risks of congenital heart disease, polydactyly, and hypospadias. The Zhuang ethnic group had higher risks of severe thalassemia, cleft lip and/or palate, and syndactyls. Overall BDs were positively correlated with air pollutants PM
conclusionThis study provides a comprehensive description of ethnic differences in BDs in Southwest China and broadens the evidence of the association between air pollution exposure during gestation and BDs.
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