ReviewCephalalgia : an international journal of headache2021
Photophobia in migraine: A symptom cluster?
Review in Cephalalgia : an international journal of headache, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- A Cerebral Basis for Visual Discomfort and Visual Stress.Vision (Basel, Switzerland) · 2026Review
- Article
- Impact of climatic factors on trigeminal neuralgia and facial neuropathy in primary care during a fourteen-year time-series study.Scientific reports · 2026Article
- Supporting Students with Migraine: Examining Current Practices and Identifying Strategies for Educational Success.Current pain and headache reports · 2025Review
- High-Density Glasses in Blepharospasm: Influence of Migraine and Early Morning Effects.Cureus · 2025Article
- Auditory discomfort and visual sensitivity.Vision research · 2025Article
- Uncovering the potential of smartphones for behavior monitoring during migraine follow-up.BMC medical informatics and decision making · 2025Article
- Photophobia and Visual Triggers in Vestibular Migraine.Neurology and therapy · 2024Article
- Article
- Genistein mitigates nitroglycerine-induced migraine: modulation of nitric oxide-mediated vasodilation and oxidative stress.Metabolic brain disease · 2024Article
- Influences of Genetic and Environmental Factors on Chronic Migraine: A Narrative Review.Current pain and headache reports · 2024Review
- Visual Snow Syndrome in Patient with Migraine: Case Report and Literature Review.Journal of clinical medicine · 2024Review
- Understanding migraine in Saudi society: An assessment of public knowledge and attitudes: A cross-sectional study.PloS one · 2024Article
- Looking for a Beam of Light to Heal Chronic Pain.Journal of pain research · 2024Review
- Auditory discomfort in visually sensitive individuals.Frontiers in psychology · 2023Article
- The Adaptation of 12-Item Utah Photophobia Symptom Impact Scale (UPSIS-12) in Turkish, Internal Consistency, and Reproducibility.Noro psikiyatri arsivi · 2023Article
- The hypothalamus may mediate migraine and ictal photophobia: evidence from Granger causality analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Photophobia in headache disorders: characteristics and potential mechanisms.Journal of neurology · 2022Review
- The Functional Network of the Visual Cortex Is Altered in Migraine.Vision (Basel, Switzerland) · 2021Article
- Retinal connections to migraine.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Photophobia is one of the most common symptoms in migraine, and the underlying mechanism is uncertain. The discovery of the intrinsically-photosensitive retinal ganglion cells which signal the intensity of light on the retina has led to discussion of their role in the pathogenesis of photophobia. In the current review, we discuss the relationship between pain and discomfort leading to light aversion (traditional photophobia) and discomfort from flicker, patterns, and colour that are also common in migraine and cannot be explained solely by the activity of intrinsically-photosensitive retinal ganglion cells. We argue that, at least in migraine, a cortical mechanism provides a parsimonious explanation for discomfort from all forms of visual stimulation, and that the traditional definition of photophobia as pain in response to light may be too restrictive. Future investigation that directly compares the retinal and cortical contributions to photophobia in migraine with that in other conditions may offer better specificity in identifying biomarkers and possible mechanisms to target for treatment.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.