Evidence map›Paper›PMID 33989937›Full record

ArticleBlood cells, molecules & diseases2021

Early iron supplementation and iron sufficiency at one month of age in NICU patients at-risk for iron deficiency.

Timothy M Bahr, Nicholas R Carr, Thomas R Christensen, Jacob Wilkes, Elizabeth A O'Brien, Kendell R German, Robin K Ohls, Diane M Ward, Robert D Christensen

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Blood cells, molecules & diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. [Expert consensus on enteral nutrition management of preterm infants (2024)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Article
  3. Article
  4. Article
  5. Impact and interactions between risk factors on the iron status of at-risk neonates.Journal of perinatology : official journal of the California Perinatal Association · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Timothy M BahrDepartment of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA. Electronic address: Tim.Bahr@hsc.utah.edu.
Nicholas R CarrDepartment of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA.
Thomas R ChristensenUniversity of Utah, Salt Lake City, UT, USA.
Jacob WilkesIntermountain Healthcare Research, Salt Lake City, UT, USA.
Elizabeth A O'BrienDepartment of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA; Intermountain Healthcare Research, Salt Lake City, UT, USA.
Kendell R GermanDepartment of Pediatrics, Division of Neonatology, University of Washington, Seattle, WA, USA.
Robin K OhlsDepartment of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA.
Diane M WardDepartment of Pathology, University of Utah Health, Salt Lake City, UT, USA; Center for Iron and Heme Disorders, University of Utah, Salt Lake City, UT, USA.
Robert D ChristensenDepartment of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA; Intermountain Healthcare Research, Salt Lake City, UT, USA; Center for Iron and Heme Disorders, University of Utah, Salt Lake City, UT, USA; Department of Pediatrics, Division of Hematology/Oncology, University of Utah Health, Salt Lake City, UT, USA.
University of Utah · USIntermountain Healthcare · USUniversity of Washington · US

Funding

Proteomics CoreU54DK110858 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anna E Beaudin, JAMES Eric COX · 2016 to 2026
$8.6M
NIDDK NIH HHS U54 DK110858
6 · The paper itself

Abstract

In order to reduce iron deficiency in neonates at-risk for iron deficiency, we implemented a guideline to increase the consistency of early iron supplementation in infants of diabetic mothers, small for gestational age neonates and very low birthweight premature neonates. Three years following implementation we performed a retrospective analysis in order to assess adherence to the guideline and to compare timing of early iron supplementation and reticulocyte-hemoglobin (RET-He) values at one month of life in at-risk infants. Adherence with early iron supplementation guidelines was 73.4% (399/543) with 51% (275/543) having RET-He values obtained at one month. Despite good adherence, 16% (44/275) had RET-He <25 pg (5th percentile for gestational age). No infants receiving red blood cell transfusion (0/20) had RET-He <25 pg vs. 26.1% (40/153) of those treated with darbepoetin (p < 0.001). There was no evidence of increased feeding intolerance (episodes of emesis/day) with early iron supplementation.

Indexed as

Intensive Care Units, NeonatalFemaleHumansInfant, NewbornIronIron DeficienciesMaleRetrospective StudiesIronIronIron deficiencyQuality improvementRET-HeSupplementation

Identifiers

PMID33989937
PMCPMC9132591
OpenAlexW3158963456

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.