Evidence map›Paper›PMID 33989742›Full record

ArticleBrain, behavior, and immunity2021

Stroke affects intestinal immune cell trafficking to the central nervous system.

David Brea, Carrie Poon, Corinne Benakis, Gabrielle Lubitz, Michelle Murphy, Costantino Iadecola, Josef Anrather

Open access · greenAbstract read
In one paragraph

Article in Brain, behavior, and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
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  6. Monocyte-derived macrophages and their roles in ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
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  11. Combined treatment withFrontiers in pharmacology · 2026
    Article
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  20. Microbiome: A Key Regulator of Body-Brain Interactions.Advances in experimental medicine and biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

David BreaFeil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, United States. Electronic address: david.brealopez@research.fchampalimaud.org.
Carrie PoonFeil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, United States.
Corinne BenakisFeil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, United States.
Gabrielle LubitzFeil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, United States.
Michelle MurphyFeil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, United States.
Costantino IadecolaFeil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, United States.
Josef AnratherFeil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, United States. Electronic address: joa2006@med.cornell.edu.
Cornell University · US

Funding

NO SYNTHASE GENE EXPRESSION AND CEREBRAL ISCHEMIC DAMAGER01NS034179 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 1995 to 2021
$5.5M
Immunomodulation by Commensal Microbiota: Role in Ischemic Brain InjuryR01NS094507 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ANRATHER, JOSEF · 2016 to 2020
$1.9M
NINDS NIH HHS R01 NS034179NINDS NIH HHS R01 NS094507
6 · The paper itself

Abstract

Stroke is an acute neurological disease with a strong inflammatory component that can be regulated by the intestinal microbiota and intestinal immune cells. Although stroke has been shown to alter immune cell populations in the gut, the dynamics of cell trafficking have not been elucidated. To study the trafficking of gut-derived immune cells after stroke, we used mice expressing the photoconvertible protein Kikume Green-Red, which turns form green to red when exposed to violet light. Mice underwent laparotomy and the small intestine was exposed to violet laser light. Immune cells were isolated from the small intestine immediately after photoconversion and 2 days later. Percentage of immune cells (CD45

Indexed as

Brain IschemiaStrokeAnimalsBrainInflammationIntestine, SmallMiceMice, Inbred C57BLImmune cell traffickingIntestinal immune systemKikume Green-Red fluorescent proteinStroke

Identifiers

PMID33989742
PMCPMC8672365
OpenAlexW3162691867

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.