Evidence map›Paper›PMID 33989715›Full record

ReviewMolecular and cellular endocrinology2021

Sex differences and aging: Is there a role of brown adipose tissue?

Jessica M Hoffman, Teresa G Valencak

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular and cellular endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Jessica M HoffmanDepartment of Biology, University of Alabama at Birmingham, 1300 University Blvd., CH464, Birmingham, AL, 35294, USA. Electronic address: jmhoffm@uab.edu.
Teresa G ValencakCollege of Animal Sciences, Zhejiang University, Zijingang Campus, 866 Yuhangtang Road, 310058, Hangzhou, PR China. Electronic address: teresa.valencak@vetmeduni.ac.at.
University of Alabama at Birmingham · USZhejiang University · CN

Funding

The metabolomic consequences of small size and long lifeR00AG059920 · NIA · AUGUSTA UNIVERSITY · PI HOFFMAN, JESSICA MARIE · 2022 to 2024
$742k
The metabolomic consequences of small size and long lifeK99AG059920 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HOFFMAN, JESSICA MARIE · 2019 to 2021
$342k
NIA NIH HHS K99 AG059920NIA NIH HHS R00 AG059920
6 · The paper itself

Abstract

In every population across the world, women live significantly longer than men; however, the underlying physiological processes that drive these sex differences in age-specific mortality are largely unknown. Recently, the role of adipose tissue in aging and longevity has been a focus of biomedical research in both humans and rodent models. Specifically, brown adipose tissue, a thermoregulatory tissue originally thought to not exist past infancy in humans, has been shown to potentially play a role in health throughout the lifespan. Females have larger adult brown adipose depots that are not just larger in size but also more efficient in non-shivering thermogenesis. This improved functioning of the brown adipose tissue may potentially lead to improved female health, and we hypothesize that this advantage may be of even bigger significance in the older population. Here, we briefly review what is known about sex differences in aging and how sex differences in brown adipose tissue may be contributing to the female lifespan advantage. These questions have usually been addressed in large experimental studies in rodents as a translational model of human aging. Overall, we propose that a better understanding of the thermogenesis-metabolism nexus is necessary in biomedical research, and sex differences in these factors may contribute to the female longevity bias seen in human populations.

Indexed as

Adipose Tissue, BrownAgingEnergy MetabolismFemaleHumansMaleSex CharacteristicsThermogenesisAgingBrown adipose tissueLongevitySex differences

Identifiers

PMID33989715
PMCPMC8195864
OpenAlexW3162910744

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.